Description

1-Methylguanine is a methylated derivative of the nucleobase guanine, serving as a key biochemical intermediate and research compound. This product is essential for scientists and manufacturers requiring high-purity modified nucleobases for advanced applications. It is primarily utilized in pharmaceutical research, biochemical studies, and as a building block in oligonucleotide synthesis.

Application

• Pharmaceutical Research & Development: Used as a reference standard and intermediate in the study of nucleic acid metabolism, methylation processes, and the development of novel therapeutics.
• Biochemical Studies: Employed in enzymatic assays and as a substrate to investigate the function of methyltransferases and other nucleic acid-modifying enzymes.
• Oligonucleotide Synthesis: Acts as a protected or modified nucleobase precursor for the solid-phase synthesis of specialized DNA or RNA sequences for diagnostic and research purposes.
• Metabolite Analysis: Serves as an analytical standard in mass spectrometry and chromatography for the detection and quantification of methylated guanine derivatives in biological samples.
• Academic & Industrial Research: A fundamental tool in molecular biology, epigenetics, and toxicology research to understand DNA damage and repair mechanisms.

Basic Information

Product Name	1-Methylguanine
CAS No.	938-85-2
Molecular Formula	C6H7N5O
Molecular Weight	165.15 g/mol
Synonyms	N1-Methylguanine; 1-Methyl-2-amino-6-hydroxypurine; 2-Amino-1-methyl-6-oxo-1,6-dihydropurine; 2-Amino-1-methyl-1H-purin-6(9H)-one; 6-Hydroxy-1-methylguanine; Guanine, 1-methyl-; N-Methylguanine; 1-Methyl guanine
EINECS	213-346-5

Quality Control

Our 1-Methylguanine is produced and tested under strict quality management protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, identity confirmation (IR, NMR), and residual solvent analysis. A Certificate of Analysis (COA) is supplied with each batch to meet the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.