Description

5-Azacytosine is a heterocyclic organic compound and a pyrimidine analog, serving as a fundamental building block in nucleoside chemistry and biochemical research. Its primary value lies in its role as a key intermediate for synthesizing nucleoside analogs, such as the antileukemic agent azacitidine, which are critical in pharmaceutical development. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors engaged in drug discovery, oncology research, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of the active pharmaceutical ingredient (API) azacitidine (Vidaza®), used in the treatment of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML).
• Biochemical Research: Used as a cytosine analog in studies of DNA/RNA methylation, epigenetics, and cellular differentiation mechanisms.
• Nucleoside Chemistry: Serves as a versatile building block for the chemical synthesis of modified nucleosides and nucleotides with potential antiviral or anticancer activity.
• Antimetabolite Development: Investigated for the development of new antimetabolite drugs that interfere with nucleic acid synthesis in rapidly dividing cells.
• Reference Standard: Employed as a high-purity analytical standard in quality control (QC) and research laboratories for method development and validation.

Basic Information

Product Name	5-Azacytosine
CAS No.	931-86-2
Molecular Formula	C4H4N4O
Molecular Weight	124.10 g/mol
Synonyms	4-Amino-1,2-dihydro-1,3,5-triazin-2-one; 5-Azacytosin; Azacytosine; 1,2-Dihydro-4-amino-1,3,5-triazin-2-one; 4-Amino-1H-1,3,5-triazin-2-one; 5-AZAC; Ladakamycin intermediate
EINECS	213-244-0

Quality Control

Our 5-Azacytosine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, identity confirmation (IR, NMR), and residual solvent analysis. A Certificate of Analysis (COA) is supplied with each batch, detailing all test results against stringent in-house specifications. Our quality commitment supports applications requiring regulatory compliance in pharmaceutical development and research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.