Description

Adenylyl-(3'-5')-Adenylyl-(3'-5')-Adenosine is a defined trinucleotide, specifically an adenosine trimer linked by 3'-5' phosphodiester bonds. This compound serves as a critical biochemical tool and reference standard for research in molecular biology and enzymology. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for studying nucleic acid metabolism, enzyme kinetics, and oligonucleotide synthesis.

Application

• Biochemical Research: Used as a substrate or reference standard for enzymes like nucleases, polymerases, and ligases to study reaction mechanisms and kinetics.
• Oligonucleotide Synthesis: Serves as a building block or intermediate in the chemical and enzymatic synthesis of longer oligonucleotides and RNA analogs.
• Diagnostic Development: Employed in the research and development of diagnostic assays and kits that target specific nucleotide sequences.
• Pharmaceutical Research: Utilized in drug discovery programs focused on nucleic acid-based therapeutics, including antisense oligonucleotides and aptamers.
• Quality Control Standard: Acts as a high-purity standard for the calibration and validation of analytical instruments (e.g., HPLC, Mass Spectrometry) in QC laboratories.
• Enzyme Characterization: Essential for determining the specificity and activity of phosphodiesterases and other nucleic acid-modifying enzymes.

Basic Information

Product Name	Adenylyl-(3'-5')-Adenylyl-(3'-5')-Adenosine
CAS No.	917-44-2
Molecular Formula	C30H37N15O19P2
Molecular Weight	933.64 g/mol
Synonyms	Adenosine(5')triphosphoric acid(5')ester with adenosine(5')triphosphoric acid(5')ester with adenosine; pppA-A-A; A(5')ppp(5')A(5')ppp(5')A; Adenosine 5'-(trihydrogen diphosphate), 5'-5'-ester with adenosine 5'-(trihydrogen diphosphate), 5'-5'-ester with adenosine; ApApA; AAA; Adenosine-adenosine-adenosine trinucleotide; 5'-Adenylyl-(3'-5')-adenylyl-(3'-5')-adenosine
EINECS	Contact for details

Quality Control

Our Adenylyl-(3'-5')-Adenylyl-(3'-5')-Adenosine is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider storing at -20°C under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (UV)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.