Description

Cortisone Sulfate CAS NO 912-25-4 is a key sulfated derivative of the corticosteroid hormone cortisone. This compound is of significant interest in pharmaceutical research and development, particularly for its role as a metabolite and potential prodrug. It is primarily utilized by research institutions, pharmaceutical manufacturers, and fine chemical suppliers engaged in steroid chemistry, drug metabolism studies, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in steroid analysis.
• Biochemical Research: Serves as a critical reagent in studies investigating steroid metabolism, sulfation pathways, and enzyme kinetics.
• Prodrug Development: Investigated for its potential in designing water-soluble prodrug forms of cortisone to improve bioavailability and delivery.
• Metabolite Identification: Essential for the identification and quantification of cortisone sulfate as a metabolite in pharmacokinetic and bioanalytical studies.
• Fine Chemical Synthesis: Acts as a specialized intermediate in the multi-step synthesis of complex steroid molecules and related bioactive compounds.

Basic Information

Product Name	Cortisone Sulfate
CAS No.	912-25-4
Molecular Formula	C21H28O6S
Molecular Weight	408.51 g/mol
Synonyms	Cortisone 21-Sulfate; 17-Hydroxy-11-dehydrocorticosterone 21-Sulfate; 11-Dehydro-17-hydroxycorticosterone 21-Sulfate; Cortisone Hydrogen Sulfate; (8S,9S,10R,13S,14S,17R)-17-Hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,4-dione 21-Sulfate
EINECS	Contact for details

Quality Control

Our Cortisone Sulfate is produced and tested under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assessment by HPLC, and control of specific impurities. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.