Description

5-Phosphorylribose-1-Pyrophosphate is a crucial phosphorylated ribose sugar and a key metabolic intermediate in nucleotide biosynthesis. Its primary commercial value lies in its role as a high-purity biochemical reagent for research and pharmaceutical development. This compound is essential for manufacturers and research institutions in the fields of enzymology, molecular biology, and drug discovery, particularly for studying purine and pyrimidine synthesis pathways.

Application

• Biochemical Research & Enzyme Assays: Serves as a critical substrate for studying enzymes like phosphoribosylpyrophosphate synthetase (PRPP synthetase) and amidophosphoribosyltransferase.
• Nucleotide Synthesis Studies: Used in in vitro systems to investigate the de novo and salvage pathways for purine and pyrimidine nucleotide production.
• Pharmaceutical Development: Acts as a key intermediate in the research and development of drugs targeting nucleotide metabolism, such as potential anticancer or antiviral agents.
• Diagnostic Reagent Manufacturing: Employed in the formulation of diagnostic kits for detecting enzyme deficiencies or metabolic disorders related to PRPP metabolism.
• Academic & Industrial R&D: A fundamental reagent for universities, contract research organizations (CROs), and biotech companies conducting metabolic pathway analysis.

Basic Information

Item	Details
Product Name	5-Phosphorylribose-1-Pyrophosphate
CAS No.	97-55-2
Molecular Formula	C5H13O14P3
Molecular Weight	390.07 g/mol
Synonyms	Phosphoribosyl Pyrophosphate; PRPP; 5-Phospho-α-D-ribose 1-diphosphate; α-D-5-Phosphoribosyl-1-pyrophosphate; 5-Phosphoribosyl 1-pyrophosphate; 1-Pyrophosphorylribose 5-phosphate; 5-O-Phosphono-α-D-ribofuranosyl diphosphate
EINECS	202-591-5

Quality Control

Our 5-Phosphorylribose-1-Pyrophosphate is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting standards required for biochemical and pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95% (Anhydrous basis)
Purity (HPLC Area %)	≥ 98.0%
Water Content (Karl Fischer)	≤ 2.0%
Solubility	Soluble in water, slightly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.