Description

Ptdins-(1,2-Dioctanoyl) (Sodium Salt) is a synthetic, short-chain phosphatidylinositol (PI) derivative where the sn-1 and sn-2 positions are esterified with octanoyl (C8:0) fatty acids. This compound matters as a critical biochemical tool for studying the structure, function, and signaling pathways of phosphoinositides, which are essential lipid second messengers in cellular processes. Researchers in biochemistry, cell biology, and pharmaceutical development need it for use as a substrate for PI-specific phospholipase C (PI-PLC), in lipid kinase/phosphatase assays, and for the preparation of lipid vesicles and micelles in membrane biophysics studies.

Application

• Biochemical Research Substrate: Used as a defined substrate for phosphatidylinositol-specific phospholipase C (PI-PLC) enzymes to study hydrolysis kinetics and product formation.
• Lipid Kinase/Phosphatase Assays: Serves as a precursor or substrate in in vitro assays for enzymes like PI 3-kinases, 4-kinases, and 5-phosphatases to investigate phosphoinositide metabolism.
• Membrane Model Systems: Incorporated into liposomes, micelles, or lipid bilayers to study protein-lipid interactions, membrane trafficking, and the biophysical properties of phosphoinositides.
• Cell Signaling Studies: Applied in cellular delivery systems to modulate intracellular phosphoinositide levels and probe downstream signaling cascades related to growth, survival, and cytoskeletal organization.
• Pharmaceutical Screening: Utilized in high-throughput screening platforms to identify and characterize novel inhibitors or activators of phosphoinositide-metabolizing enzymes, a target area for cancer and metabolic diseases.
• Mass Spectrometry Standard: Acts as a quantitative internal standard or reference compound in lipidomic analyses using LC-MS/MS for accurate profiling of cellular PI species.

Basic Information

Item	Details
Product Name	Ptdins-(1,2-Dioctanoyl) (Sodium Salt)
CAS No.	899827-36-2
Molecular Formula	C29H52NaO13P
Molecular Weight	638.68 g/mol
Synonyms	1,2-Di-O-octanoyl-sn-glycero-3-phospho-(1'-myo-inositol) Sodium Salt; PI(8:0/8:0) Sodium Salt; Phosphatidylinositol DiC8 Sodium Salt; 1,2-Dioctanoyl Phosphatidylinositol Sodium Salt; PtdIns-(C8) Sodium Salt; sn-Glycero-3-phosphoinositol (sodium salt), 1,2-di-O-octanoyl; L-α-Phosphatidylinositol (sodium salt), 1,2-dihexanoyl (common misnomer); Synthetic PI (C8) Sodium Salt
EINECS	Contact for details

Quality Control

Our Ptdins-(1,2-Dioctanoyl) (Sodium Salt) is produced under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS). Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). For long-term storage, keep under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay (Phosphorus)	≥ 85% (by weight)
Solubility	Soluble in chloroform, methanol, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.