Description

1,3-Bis(4-Methoxybenzyl)-5-Fluorouracil is a fluorinated uracil derivative with a unique bis-benzyl ether structure. This compound is a valuable pharmaceutical intermediate and research chemical for the development of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D departments and contract research organizations (CROs) engaged in oncology and antiviral drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel fluoropyrimidine-based anticancer and antiviral drug candidates.
• Biochemical Research: Used as a reference standard or probe in studies targeting thymidylate synthase and other enzymes in nucleotide metabolism.
• Preclinical Development: Serves as a starting material for generating analogs to study structure-activity relationships (SAR) and optimize pharmacokinetic properties.
• Academic Research: Employed in university and institutional labs for investigating fluorouracil prodrug mechanisms and delivery systems.
• Process Chemistry: Used in route scouting and scale-up studies for the manufacturing of complex active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1,3-Bis(4-Methoxybenzyl)-5-Fluorouracil
CAS No.	897304-05-1
Molecular Formula	C21H21FN2O4
Molecular Weight	384.40 g/mol
Synonyms	5-Fluoro-1,3-bis[(4-methoxyphenyl)methyl]pyrimidine-2,4(1H,3H)-dione; 1,3-Di(4-methoxybenzyl)-5-fluorouracil; 5-Fluoro-1,3-bis(4-methoxybenzyl)uracil; 1,3-Bis(p-methoxybenzyl)-5-fluorouracil; 5-FU bis(4-methoxybenzyl) derivative
EINECS	Contact for details

Quality Control

Our 1,3-Bis(4-Methoxybenzyl)-5-Fluorouracil is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.