Description

tert-Butyl 3-(Tosyloxymethyl)Azetidine-1-Carboxylate is a high-value, protected azetidine derivative that serves as a crucial synthetic intermediate in modern organic chemistry. Its primary value lies in its dual functionality, where the tosyloxymethyl group acts as a versatile electrophilic handle and the Boc group provides orthogonal protection for the azetidine nitrogen. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries who require reliable, high-purity building blocks for constructing complex nitrogen-containing heterocycles and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel azetidine-based drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced crop protection agents that incorporate the azetidine ring for enhanced biological activity.
• Chemical Biology & Proteomics: Serves as a precursor for designing activity-based probes (ABPs) and molecular tags that target specific enzymes or biological pathways.
• Material Science Research: Employed in the creation of novel polymers and functional materials where the azetidine moiety imparts specific chemical or physical properties.
• Medicinal Chemistry SAR Studies: Facilitates structure-activity relationship (SAR) exploration by allowing for the systematic modification of the azetidine scaffold.
• Peptidomimetics: Acts as a constrained, non-proteinogenic amino acid analog in the design of peptide mimics with improved metabolic stability and bioavailability.

Basic Information

Item	Details
Product Name	tert-Butyl 3-(Tosyloxymethyl)Azetidine-1-Carboxylate
CAS No.	892408-42-3
Molecular Formula	C16H23NO5S
Molecular Weight	341.42 g/mol
Synonyms	1-Boc-3-(tosyloxymethyl)azetidine; tert-Butyl 3-[(4-methylphenyl)sulfonyloxy]methyl]azetidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-[(p-toluenesulfonyloxy)methyl]azetidine; 3-[(Tosyloxy)methyl]-1-(tert-butoxycarbonyl)azetidine; Azetidine-1-carboxylic acid, 3-[[(4-methylphenyl)sulfonyl]oxy]methyl]-, 1,1-dimethylethyl ester; 1-Boc-3-(OTs-CH2)-azetidine; Boc-Azetidine-3-CH2-OTs
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(Tosyloxymethyl)Azetidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and KF for moisture content, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.