Description

Dspe-Peg-Oh CAS NO 892144-24-0 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a distearoylphosphatidylethanolamine (DSPE) lipid anchor and a terminal hydroxyl (OH) group. This unique amphiphilic structure is critical for creating stable, biocompatible nanostructures in advanced pharmaceutical and biomedical applications. It is an essential material for researchers and manufacturers in the fields of drug delivery, nanomedicine, and bioconjugation who require precise surface modification and controlled assembly.

Application

• Liposomal Drug Delivery Systems: As a key component for PEGylating liposomes (stealth liposomes) to enhance circulation time and reduce immunogenicity.
• Nanoparticle Functionalization: For surface modification of polymeric or inorganic nanoparticles to improve solubility, stability, and targeting capabilities.
• Micelle and Vesicle Formation: Used as a building block for self-assembling nanostructures for encapsulating hydrophobic drugs or imaging agents.
• Bioconjugation and Linker Chemistry: The terminal hydroxyl group provides a site for further chemical modification and attachment of ligands, dyes, or therapeutic molecules.
• Biomaterial Coatings: Applied to create hydrophilic, protein-resistant surfaces on medical devices and implants.
• Diagnostic Reagent Preparation: In the formulation of contrast agents and other diagnostic tools requiring stable aqueous dispersion.

Basic Information

Product Name	Dspe-Peg-Oh
CAS No.	892144-24-0
Molecular Formula	Contact for details
Molecular Weight	Variable (PEG chain length dependent)
Synonyms	1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)]; DSPE-PEG-OH; DSPE-PEGn-OH (n=PEG unit count); Distearoylphosphatidylethanolamine-Polyethylene Glycol-Hydroxyl; PEGylated DSPE; Phospholipid-PEG-OH; Amphiphilic PEG Lipid; Stealth Lipid-PEG Conjugate
EINECS	Contact for details

Quality Control

Our Dspe-Peg-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, NMR for structural confirmation, and mass spectrometry for molecular weight verification. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing specifications for purity, PEG chain length distribution, and critical impurities.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to warm to room temperature before opening to minimize condensation. For long-term storage, keep under an inert atmosphere (argon or nitrogen).

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (Functional Groups)	≥ 90%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
PEG Molecular Weight (SEC/MS)	As per ordered grade (e.g., 2000, 3400, 5000 Da)
Dispersity (Đ)	≤ 1.05

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.