Description

n-Acetyl-2'-C-Methyl-Guanosine 2',3',5'-Tribenzoate is a key, high-purity nucleoside derivative used as a critical building block in advanced pharmaceutical research and development. This compound matters for its role in the synthesis of modified RNA and nucleotide analogs, enabling the exploration of novel therapeutic mechanisms. It is primarily needed by research institutions and pharmaceutical companies engaged in antiviral drug discovery, oncology research, and the development of mRNA-based therapies.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Antiviral Research: Used in the development of nucleotide analogs targeting RNA viruses, including hepatitis C virus (HCV) and other emerging pathogens.
• Oncology Drug Discovery: Employed in creating modified nucleosides that can interfere with cancer cell proliferation and DNA/RNA synthesis.
• mRNA Technology: Acts as a specialty raw material for synthesizing cap analogs and other modified nucleotides to enhance mRNA stability and translational efficiency.
• Biochemical Research: Utilized as a substrate or inhibitor in enzymatic studies to understand nucleic acid metabolism and related pathways.
• Process Development: Supports scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs) in a GMP environment.

Basic Information

Item	Details
Product Name	n-Acetyl-2'-C-Methyl-Guanosine 2',3',5'-Tribenzoate
CAS No.	890131-90-5
Molecular Formula	C33H31N5O9
Molecular Weight	641.63 g/mol
Synonyms	2'-C-Methylguanosine-2',3',5'-tribenzoate, N-Acetyl Derivative; 2'-C-Methyl-N2-acetyl-2',3',5'-tribenzoylguanosine; 1-(2,3,5-Tri-O-benzoyl-2-C-methyl-β-D-ribofuranosyl)-N2-acetylguanine; 2'-C-Methylguanosine tribenzoate (acetylated); 890131-90-5; Guanosine, 2'-C-methyl-, 2',3',5'-tribenzoate, N-acetyl-
EINECS	Contact for details

Quality Control

Our n-Acetyl-2'-C-Methyl-Guanosine 2',3',5'-Tribenzoate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) detailing purity, related substances, and residual solvents are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.