Description

n-Succinimidyloxycarbonylundecyl Methanethiosulfonate is a heterobifunctional crosslinking reagent featuring an amine-reactive N-hydroxysuccinimide (NHS) ester and a thiol-reactive methanethiosulfonate (MTS) group, separated by a long, flexible 11-carbon spacer. This compound matters for its ability to create stable, covalent linkages between proteins, peptides, or other biomolecules containing primary amines and free thiols, enabling precise bioconjugation and surface modification. It is primarily needed by researchers and manufacturers in the fields of bioconjugation chemistry, proteomics, antibody-drug conjugate (ADC) development, and biosensor fabrication.

Application

• Bioconjugation and Protein Labeling: For site-specific covalent attachment of fluorescent dyes, enzymes, or other probes to antibodies, proteins, or peptides via amine and thiol groups.
• Antibody-Drug Conjugate (ADC) Linker Chemistry: As a critical component in the synthesis of linkers for connecting cytotoxic drugs to monoclonal antibodies.
• Surface Functionalization: To immobilize biomolecules onto gold surfaces, nanoparticles, or biosensor chips via the thiol-reactive end, with the NHS ester available for subsequent coupling.
• Crosslinking Studies: To investigate protein-protein interactions or to stabilize protein complexes by introducing covalent crosslinks.
• Polymer Modification: For introducing functional groups into polymers or hydrogels to create bioactive materials for tissue engineering or drug delivery.
• Affinity Chromatography Resin Preparation: In the synthesis of ligands for affinity columns by coupling specific proteins or small molecules to solid supports.

Basic Information

Product Name	n-Succinimidyloxycarbonylundecyl Methanethiosulfonate
CAS No.	887407-54-7
Molecular Formula	C₁₇H₂₈N₂O₆S₂
Molecular Weight	420.54 g/mol
Synonyms	11-((2,5-Dioxopyrrolidin-1-yl)oxy)-11-oxoundecyl methanesulfonothioate; NHS-Undecane-MTS; Succinimidyl 11-(methanesulfonothioyl)undecanoate; 1-((11-(Methanesulfonothioyl)undecanoyl)oxy)pyrrolidine-2,5-dione; Heterobifunctional Crosslinker, NHS-MTS; Amine-to-Thiol Crosslinker, 11.0 Å Spacer; MTS-NHS Ester (C11); Undecyl NHS-MTS
EINECS	Contact for details

Quality Control

Our n-Succinimidyloxycarbonylundecyl Methanethiosulfonate is manufactured under strict quality protocols to ensure batch-to-batch consistency and high reactivity. Each lot undergoes rigorous analytical testing, including HPLC for purity assessment, NMR for structural confirmation, and mass spectrometry for identity verification. Certificates of Analysis (COA) detailing all specifications are available upon request to support your research and quality assurance documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.