Description

Boc-Aoa-Nh-(Ch2)2-S-S-Pyr is a specialized heterobifunctional crosslinking reagent featuring a Boc-protected aminooxy group and a pyridyl disulfide moiety. This compound is engineered for the site-specific conjugation of biomolecules, enabling the formation of stable oxime bonds with carbonyl groups while offering a reversible disulfide linkage for controlled release or downstream modification. It is an essential tool for researchers and manufacturers in the fields of bioconjugation, antibody-drug conjugate (ADC) development, and advanced materials science, where precise and stable chemical linkages are paramount.

Application

• Bioconjugation and ADC Development: Site-specific conjugation of antibodies, proteins, or peptides via aminooxy-aldehyde/ketone chemistry, with a cleavable linker for payload release.
• Polymer and Biomaterial Functionalization: Modification of polymer backends or hydrogel matrices to introduce bioactive ligands or crosslinking points.
• Surface Immobilization: Crafting functionalized surfaces for biosensors, microarrays, or diagnostic assays by attaching probe molecules.
• Chemical Biology Probes: Synthesis of activity-based probes or affinity tags for studying protein function and interactions.
• Nanoparticle and Liposome Labeling: Conjugation of targeting ligands or imaging agents to nanocarriers for therapeutic or diagnostic applications.
• Intermediate in Organic Synthesis: Serving as a key building block for the synthesis of more complex heterobifunctional or multifunctional linkers.

Basic Information

Product Name	Boc-Aoa-Nh-(Ch2)2-S-S-Pyr
CAS No.	887407-46-7
Molecular Formula	C15H21N3O4S2
Molecular Weight	371.48 g/mol
Synonyms	1-tert-Butyl 2-[2-[(2-pyridinyldithio)ethylamino]-2-oxoethyl] propanedioate; Boc-Aminooxyacetic Acid SS-Pyridyl Ester; Boc-AOA-Pyridyl Disulfide; tert-Butyl N-[(2-{2-[(pyridin-2-yldisulfanyl)ethylamino]-2-oxoethoxy}carbonyl)amino]oxyacetate; Boc-Aoa-NH-(CH2)2-S-S-2-Pyridyl; Boc-AOA-SSPy; Heterobifunctional Crosslinker, Boc-AOA/SS-Pyridyl
EINECS	Contact for details

Quality Control

Every batch of Boc-Aoa-Nh-(Ch2)2-S-S-Pyr is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and performance consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and mass spectrometry analysis. Our quality commitment aligns with the standards required for research and development in pharmaceutical and biotech applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, keep under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.