Description

16-Methanethiosulfonyl Hexadecanoic Acid is a specialized long-chain fatty acid derivative featuring a reactive methanethiosulfonate (MTS) functional group. This compound is a critical intermediate and biochemical tool, valued for its ability to selectively modify cysteine residues in proteins and peptides via disulfide bond formation. It is primarily utilized by research institutions and pharmaceutical developers engaged in bioconjugation, site-directed spin labeling, and the study of protein structure-function relationships.

Application

• Bioconjugation Reagent: For the site-specific labeling of proteins, antibodies, and peptides to create stable conjugates for diagnostics and therapeutics.
• Protein Structure Analysis: Used in Electron Paramagnetic Resonance (EPR) spectroscopy as a spin-labeling agent to probe protein dynamics and conformational changes.
• Chemical Biology Research: A key tool for studying cysteine accessibility, protein-protein interactions, and enzyme mechanisms.
• Pharmaceutical Intermediate: Serves as a building block in the synthesis of more complex drug candidates and targeted delivery systems.
• Surface Functionalization: Employed to modify nanoparticles, biosensors, and other material surfaces with bioactive molecules.

Basic Information

Product Name	16-Methanethiosulfonyl Hexadecanoic Acid
CAS No.	887406-81-7
Molecular Formula	C₁₇H₃₄O₄S₂
Molecular Weight	366.57 g/mol
Synonyms	16-(Methanethiosulfonyl)palmitic acid; MTS-Palmitic Acid; Hexadecanoic acid, 16-(methanethiosulfonyl)-; 16-MTS-hexadecanoic acid; Palmitic acid MTS derivative; MTSSL-C16 acid; S-Methanethiosulfonyl 16-mercaptohexadecanoic acid; (16-Methanethiosulfonyl)palmitate
EINECS	Contact for details

Quality Control

Our 16-Methanethiosulfonyl Hexadecanoic Acid is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is characterized by NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. The compound is light-sensitive and should be handled under controlled conditions to prevent decomposition. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.