Description

Peg9-Tos CAS NO 886469-23-4 is a high-purity polyethylene glycol (PEG) derivative functionalized with a tosylate (p-toluenesulfonate) group at one terminus. This compound is a critical bifunctional linker and reagent in advanced organic synthesis and bioconjugation, enabling the controlled introduction of PEG chains to enhance solubility, stability, and pharmacokinetic properties. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors developing novel therapeutics, diagnostic agents, and specialty polymers.

Application

• Pharmaceutical Intermediates: Serves as a key building block for the synthesis of PEGylated active pharmaceutical ingredients (APIs) and prodrugs.
• Bioconjugation Reagent: Used to attach polyethylene glycol chains to proteins, peptides, and antibodies to improve their stability and reduce immunogenicity.
• Polymer Chemistry: Acts as a macro-initiator or functional monomer for the synthesis of block copolymers and functionalized hydrogels.
• Surface Modification: Employed to create hydrophilic, non-fouling coatings on medical devices and diagnostic platforms.
• Linker for Solid-Phase Synthesis: Utilized in peptide and oligonucleotide synthesis to introduce a hydrophilic PEG spacer.
• Nanoparticle Functionalization: Facilitates the surface modification of liposomes and polymeric nanoparticles for targeted drug delivery systems.
• Crosslinking Agent: Used in the preparation of crosslinked polymer networks with tailored degradation profiles.
• Research & Development: A valuable tool in academic and industrial R&D for exploring new drug delivery modalities and biomaterials.

Basic Information

Product Name	Peg9-Tos
CAS No.	886469-23-4
Molecular Formula	C24H42O12S
Molecular Weight	554.66 g/mol
Synonyms	9-(p-Toluenesulfonyl)-3,6,9,12,15,18,21,24,27-nonaoxanonacosan-1-ol; PEG9 Tosylate; Poly(ethylene glycol) methyl ether tosylate (n~9); mPEG9-OTs; Monomethoxy PEG9 Tosylate; 2-[2-[2-[2-[2-[2-[2-[2-[2-(4-Methylbenzenesulfonyloxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol; α-Methyl-ω-tosyl-pentaethylene glycol; Tosyl-PEG9-OH
EINECS	Contact for details

Quality Control

Our Peg9-Tos is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical and research applications. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C. This product is hygroscopic (moisture-sensitive). Allow the container to reach ambient temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.