Description

α-Galnac-Peg3-Azide >=95% is a high-purity, heterobifunctional linker molecule designed for advanced bioconjugation and click chemistry applications. This compound is critical for researchers and developers creating targeted biotherapeutics and diagnostic probes, offering a reliable and efficient pathway for site-specific modifications. It is primarily utilized in the pharmaceutical, biotechnology, and life science research sectors for the development of antibody-drug conjugates (ADCs), glycan engineering, and the synthesis of complex biomolecular assemblies.

Application

• Antibody-Drug Conjugate (ADC) Development: Serves as a key linker for the site-specific conjugation of cytotoxic payloads to monoclonal antibodies, enhancing therapeutic efficacy and stability.
• Glycobiology and Glycoengineering: Used to introduce azide-functionalized GalNAc moieties onto proteins, peptides, or surfaces for studying carbohydrate-protein interactions or creating targeted delivery systems.
• Click Chemistry Bioconjugation: The terminal azide group enables efficient, copper-catalyzed or strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-modified molecules for rapid and selective labeling.
• Proteomics and Biomarker Discovery: Facilitates the tagging and enrichment of glycoproteins or other biomolecules for mass spectrometry analysis and functional studies.
• Polymer and Material Science: Acts as a functional building block for synthesizing smart polymers, hydrogels, or functionalized surfaces with bioactive properties.
• Diagnostic Probe Synthesis: Enables the construction of imaging agents and diagnostic tools by conjugating targeting ligands (via the GalNAc) to reporter molecules (via the azide).

Basic Information

Product Name	α-Galnac-Peg3-Azide >=95%
CAS No.	882873-70-3
Molecular Formula	C₂₀H₃₆N₄O₁₁
Molecular Weight	508.52 g/mol
Synonyms	N-[(2S,3R,4R,5R,6R)-5-Acetamido-4,6-dihydroxy-2-(hydroxymethyl)oxan-3-yl]-2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]acetamide; α-GalNAc-PEG3-Azide; N-Acetyl-α-D-galactosamine-PEG3-azide; GalNAc-α-PEG3-N3; Azido-PEG3-α-GalNAc; 2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]-N-[(2S,3R,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(1-hydroxyethylidene)amino]oxan-3-yl]acetamide
EINECS	Contact for details

Quality Control

Every batch of α-Galnac-Peg3-Azide is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard >=95% purity is verified by HPLC, with complementary characterization by NMR and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.