Description

Tos-Peg3-Ch2Co2Tbu CAS NO 882518-89-0 is a specialized heterobifunctional polyethylene glycol (PEG) linker featuring a tosylate (Tos) leaving group and a protected carboxylic acid (t-butyl ester). This compound is a critical reagent in bioconjugation and pharmaceutical development, enabling the controlled attachment of molecules through orthogonal reactive handles. It is primarily utilized by researchers and manufacturers in the fields of biopharmaceuticals, proteomics, and advanced material science for constructing antibody-drug conjugates (ADCs), peptide modifications, and functionalized surfaces.

Application

• Antibody-Drug Conjugate (ADC) Linker Synthesis: Serves as a key intermediate for constructing cleavable or non-cleavable linkers that connect cytotoxic payloads to monoclonal antibodies.
• PEGylation Reagent: Used to introduce hydrophilic PEG spacers onto peptides, proteins, or small molecules to improve solubility, stability, and pharmacokinetic profiles.
• Proteomics and Cross-linking: Functions as a heterobifunctional cross-linker for studying protein-protein interactions or immobilizing biomolecules onto solid supports.
• Polymer and Dendrimer Functionalization: Acts as a building block for synthesizing functionalized polymers and dendrimers with tailored surface chemistry.
• Diagnostic Reagent Development: Employed in the creation of contrast agents or labeled probes for imaging and diagnostic assays.
• Solid-Phase Peptide Synthesis (SPPS): Used as a protected linker for the synthesis of modified peptides on resin.

Basic Information

Product Name	Tos-Peg3-Ch2Co2Tbu
CAS No.	882518-89-0
Molecular Formula	C22H36O9S
Molecular Weight	476.58 g/mol
Synonyms	2,5,8,11-Tetraoxatetradecan-14-oic acid, 13-[[(4-methylphenyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester; 1-tert-Butyl 14-[(4-methylphenyl)sulfonyl] 2,5,8,11-tetraoxatetradecanedioate; Tos-PEG3-t-butyl ester; PEG3 Tosylate t-Butyl Ester; 4-Methylbenzenesulfonic Acid 3,6,9-Trioxaundecan-11-yl Ester t-Butyl Ester; Heterobifunctional PEG Linker Tos-PEG3-COOtBu; tert-Butyl 11-((tosyloxy)methyl)-3,6,9-trioxaundecanoate
EINECS	Contact for details

Quality Control

Our Tos-Peg3-Ch2Co2Tbu is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided to support research and cGMP manufacturing applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.