Description

Bis(Sulfosuccinimidyl)Adipate Sodium Salt is a homobifunctional, water-soluble N-hydroxysulfosuccinimide (Sulfo-NHS) ester crosslinker. This compound is essential for creating stable amide bonds between primary amines under mild, aqueous conditions, offering superior solubility over its NHS ester counterparts. It is a critical reagent for researchers and manufacturers in bioconjugation, antibody-drug conjugate (ADC) development, and protein immobilization for diagnostic assays and biosensors.

Application

• Bioconjugation and Protein Crosslinking: For coupling peptides, proteins, antibodies, and other amine-containing biomolecules in aqueous buffers.
• Antibody-Drug Conjugate (ADC) Linker Chemistry: Serves as a cleavable or non-cleavable linker component for attaching cytotoxic payloads to monoclonal antibodies.
• Diagnostic Assay Development: Immobilization of capture antibodies or antigens onto amine-functionalized microplates, membranes, or sensor surfaces.
• Biomaterial and Hydrogel Fabrication: Crosslinking amine-modified polymers (e.g., chitosan, polyethyleneimine) to create scaffolds for tissue engineering and drug delivery.
• Nanoparticle Functionalization: Conjugation of targeting ligands (e.g., peptides, antibodies) to the surface of amine-coated nanoparticles for targeted therapy and imaging.
• Affinity Chromatography Resin Preparation: Covalent attachment of ligands to agarose or other chromatographic supports for protein purification.

Basic Information

Product Name	Bis(Sulfosuccinimidyl)Adipate Sodium Salt
CAS No.	881415-69-6
Molecular Formula	C16H18N2Na2O14S2
Molecular Weight	588.42 g/mol
Synonyms	BS3 Sodium Salt; BS3 (Sodium Salt); Disodium 3,3'-((1,6-dioxo-1,6-hexanediyl)bis(oxy))bis(4-oxo-4-sulfobutanoate); Disulfosuccinimidyl Adipate; Sulfo-BS3; BS(PEG)9 (common misnomer, verify structure); Bis(sulfosuccinimidyl) adipate; Water-soluble BS3
EINECS	Contact for details

Quality Control

Our Bis(Sulfosuccinimidyl)Adipate Sodium Salt is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional suitability is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Solubility (Water)	Clear, colorless solution at 10 mg/mL
Water Content (KF)	≤ 2.0 %
Functional Activity	Conforms (by amine coupling test)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.