Description

R-3,3'-Bis([1,1'-Biphenyl]-4-Yl)-5,5',6,6',7,7',8,8'-Octahydro-[1,1'-Binaphthalene]-2,2'-Diol is a sophisticated chiral ligand and building block of significant interest in advanced organic synthesis. Its value lies in its rigid, three-dimensional structure which is highly effective for inducing stereoselectivity in catalytic reactions. This compound is essential for researchers and process chemists in the pharmaceutical and fine chemical industries developing enantiomerically pure active pharmaceutical ingredients (APIs) and specialty materials.

Application

• Asymmetric Catalysis: Serves as a privileged chiral ligand or precursor for transition metal catalysts in enantioselective C-C bond-forming reactions (e.g., Suzuki-Miyaura coupling, Heck reaction).
• Pharmaceutical Intermediate: A key chiral scaffold in the synthesis of complex, biologically active molecules targeting specific enantiomers for improved efficacy and safety.
• Material Science Research: Used in the development of chiral organic frameworks (COFs), liquid crystals, or advanced polymeric materials with specific optical properties.
• Methodology Development: Employed in academic and industrial R&D for developing new catalytic protocols and exploring novel reaction pathways.
• Chiral Resolution Agent: Can be utilized to separate enantiomers of racemic mixtures through diastereomeric salt formation or chiral stationary phase preparation.

Basic Information

Product Name	R-3,3'-Bis([1,1'-Biphenyl]-4-Yl)-5,5',6,6',7,7',8,8'-Octahydro-[1,1'-Binaphthalene]-2,2'-Diol
CAS No.	878049-66-2
Molecular Formula	C54H46O2
Molecular Weight	726.95 g/mol
Synonyms	(R)-H8-BINOL-Biph; (R)-3,3'-Bis(4-biphenylyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl-2,2'-diol; (R)-Octahydrobinaphthol biphenyl derivative; R-3,3'-Di([1,1'-biphenyl]-4-yl)-H8-BINOL; R-3,3'-Bis(biphenyl-4-yl)-5,5',6,6',7,7',8,8'-octahydro-[1,1'-binaphthalene]-2,2'-diol; (R)-H8-BINOL-3,3'-dibiphenyl; Chiral BINOL-based ligand
EINECS	Contact for details

Quality Control

Our production of R-3,3'-Bis([1,1'-Biphenyl]-4-Yl)-5,5',6,6',7,7',8,8'-Octahydro-[1,1'-Binaphthalene]-2,2'-Diol adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical characterization, including HPLC for chiral purity and chemical assay, NMR for structural confirmation, and specific optical rotation measurement. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry place. The compound is light-sensitive and easily oxidized; therefore, exposure to air and light should be minimized during handling.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Specific Optical Rotation	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.