Description

(2R,5R)-5-Benzyl-3-Methyl-2-(5-Methyl-2-Furyl)-4-Imidazolidinone is a high-purity, chiral imidazolidinone derivative that serves as a critical building block and chiral auxiliary in advanced organic synthesis. Its defined stereochemistry makes it an invaluable reagent for inducing enantioselectivity in asymmetric transformations, directly impacting the efficiency and yield of complex molecule production. This compound is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality chiral intermediates for API synthesis and catalyst development.

Application

• As a chiral auxiliary or ligand in asymmetric catalysis for the synthesis of enantiomerically pure pharmaceuticals.
• An advanced intermediate in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral agents.
• A key building block for constructing complex heterocyclic compounds in medicinal chemistry and agrochemical research.
• Utilized in process chemistry for scaling up enantioselective synthetic routes in GMP and non-GMP environments.
• Employed in academic and industrial R&D for methodological studies in stereoselective synthesis.
• Serving as a reference standard for analytical method development and quality control in chiral compound analysis.

Basic Information

Product Name	(2R,5R)-5-Benzyl-3-Methyl-2-(5-Methyl-2-Furyl)-4-Imidazolidinone
CAS No.	877303-84-9
Molecular Formula	C₁₆H₁₈N₂O₂
Molecular Weight	270.33 g/mol
Synonyms	(2R,5R)-5-Benzyl-3-methyl-2-(5-methylfuran-2-yl)imidazolidin-4-one; (2R,5R)-5-Benzyl-3-methyl-2-(5-methyl-2-furanyl)-4-imidazolidinone; (2R,5R)-5-Benzyl-3-methyl-2-(5-methylfuran-2-yl)-1,3-diazolidin-4-one; (2R,5R)-5-Benzyl-3-methyl-2-(5-methyl-2-furyl)imidazolidin-4-one; Chiral Imidazolidinone Auxiliary; MacMillan Catalyst Derivative; Furan-Containing Imidazolidinone
EINECS	Contact for details

Quality Control

Our (2R,5R)-5-Benzyl-3-Methyl-2-(5-Methyl-2-Furyl)-4-Imidazolidinone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.