Description

Propargyl-Peg4-Tos is a high-purity, heterobifunctional polyethylene glycol (PEG) linker featuring a propargyl group and a tosylate leaving group, enabling versatile conjugation chemistry. This compound is critical for creating stable, well-defined bioconjugates and functionalized materials with precise control over architecture and spacing. It is an essential reagent for researchers and manufacturers in pharmaceutical development, bioconjugation, and advanced material science.

Application

• Bioconjugation and ADC Development: Used as a linker to attach cytotoxic drugs, fluorescent dyes, or other payloads to antibodies, proteins, or peptides via click chemistry and nucleophilic substitution.
• Polymer and Dendrimer Synthesis: Serves as a functional monomer or cross-linking agent for constructing PEG-based hydrogels, smart polymers, and dendritic structures with tailored properties.
• Surface Functionalization: Enables the modification of nanoparticles, quantum dots, biosensors, and other material surfaces with bioactive molecules for targeted delivery and diagnostics.
• Chemical Biology Probes: Facilitates the synthesis of activity-based probes and affinity labels for studying enzyme function and protein-protein interactions.
• Pharmaceutical Intermediates: Acts as a key building block in the synthesis of complex drug candidates, particularly those requiring PEGylation to enhance solubility and pharmacokinetics.
• Diagnostic Reagent Formulation: Employed in the development of diagnostic kits and assays that require stable, site-specific labeling of biomolecules.

Basic Information

Product Name	Propargyl-Peg4-Tos
CAS No.	875770-32-4
Molecular Formula	C₂₀H₂₈O₈S
Molecular Weight	428.50 g/mol
Synonyms	Propargyl-PEG4-tosylate; 2,5,8,11-Tetraoxatetradec-13-yne-14-yl 4-methylbenzenesulfonate; Propargyl tetraethylene glycol tosylate; Tos-PEG4-Propargyl; Propargyl-O-(CH₂CH₂O)₄-Ts; 4-Methylbenzenesulfonic acid 2,5,8,11-tetraoxatetradec-13-yn-14-yl ester; Propargyl PEG4 OTos; Heterobifunctional PEG linker (Propargyl/Tosylate)
EINECS	Contact for details

Quality Control

Our Propargyl-Peg4-Tos is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.