Description

Mpeg16-Sh is a specialized methoxy polyethylene glycol (mPEG) derivative, a key building block in advanced pharmaceutical and bioconjugation chemistry. Its primary value lies in providing a reactive site for the controlled attachment of therapeutic molecules, enabling the creation of next-generation drug delivery systems. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic industries developing PEGylated drugs, protein conjugates, and targeted therapies. Its consistent quality ensures reliable performance in sensitive synthetic pathways.

Application

• Pharmaceutical PEGylation: Conjugation to proteins, peptides, and small molecule drugs to enhance solubility, prolong circulation half-life, and reduce immunogenicity.
• Bioconjugation Linker: Serves as a functionalized spacer or linker for attaching targeting ligands, dyes, or other payloads to biological molecules.
• Polymer-Drug Conjugate Synthesis: A critical monomer or intermediate in the synthesis of sophisticated polymer-drug conjugates for controlled release applications.
• Diagnostic Reagent Preparation: Used to modify antibodies, enzymes, or other biomolecules for use in immunoassays and diagnostic kits to improve stability and performance.
• Surface Functionalization: Modification of nanoparticles, liposomes, or medical device surfaces to impart stealth properties (reduce protein adsorption) and improve biocompatibility.
• Research & Development: A valuable tool in academic and industrial R&D for exploring new bioconjugation strategies and novel therapeutic modalities.

Basic Information

Product Name	Mpeg16-Sh
CAS No.	874820-38-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	mPEG16-SH; Methoxy PEG Thiol; α-Methoxy-ω-mercapto poly(ethylene glycol); Poly(ethylene glycol) methyl ether thiol (MW ~800); PEG-Thiol (n~16); HS-PEG-OCH₃; Thiol-terminated methoxy polyethylene glycol; 2-[2-(2-Methoxyethoxy)ethoxy]ethanethiol (oligomer)
EINECS	Contact for details

Quality Control

Every batch of Mpeg16-Sh is manufactured under strict quality management protocols. We employ advanced analytical techniques including HPLC, NMR, and titration methods to ensure high purity, precise molecular weight distribution, and functional group integrity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the certificate of analysis. This product is easily oxidized and moisture-sensitive; ensure containers are sealed immediately after use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (Purity, HPLC)	≥ 95.0%
Molecular Weight (Mn, SEC)	~800 g/mol (n~16)
Thiol Content (Titration)	≥ 90% of theoretical
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.