Description

Bilirubin Acyl-B-D-Glucuronide (Mixture of Monoglucuronides) is a crucial conjugated metabolite of bilirubin, formed in the liver via the enzymatic process of glucuronidation. This compound is essential for research into hepatic function, bilirubin metabolism, and the diagnosis of related disorders such as jaundice and Crigler-Najjar syndrome. It serves as a vital reference standard and biochemical tool for pharmaceutical development, clinical diagnostics, and advanced life science research.

Application

• Pharmaceutical Reference Standard: Used for the calibration, validation, and quality control of analytical methods in drug development and manufacturing.
• Clinical Diagnostics Research: Critical for developing and verifying assays to measure bilirubin and its conjugates in biological samples for disease diagnosis.
• Metabolic Pathway Studies: Employed in research to elucidate the mechanisms of bilirubin conjugation, transport, and excretion in hepatobiliary function.
• Enzyme Activity Assays: Serves as a substrate for studying the activity of UDP-glucuronosyltransferase (UGT) enzymes.
• Biochemical Research: Used in studies of liver physiology, neonatal jaundice, and genetic disorders affecting bilirubin metabolism.
• Toxicology and Safety Assessment: Applied in investigations of drug-induced liver injury and the safety profile of new chemical entities.

Basic Information

Product Name	Bilirubin Acyl-B-D-Glucuronide (Mixture of Monoglucuronides)
CAS No.	874448-90-5
Molecular Formula	C45H52N4O18
Molecular Weight	936.92 g/mol
Synonyms	Bilirubin Monoglucuronide; Bilirubin β-D-Glucuronide; Bilirubin Glucuronide Isomer; Delta Bilirubin; Bilirubin Conjugate; BMRG; Conjugated Bilirubin; Bilirubin Diglucuronide (related mixture component)
EINECS	Contact for details

Quality Control

Our Bilirubin Acyl-B-D-Glucuronide is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and diagnostic applications. A Certificate of Analysis (COA) detailing specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Orange to red-brown solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95% (Total of monoglucuronide isomers)
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.