Description

5'-o-(Dimethoxytrityl)-5-Fluoro-O4-(2,4,6-Trimethylphenyl)-2'-o-Methyluridine is a sophisticated, high-purity nucleoside derivative specifically engineered for advanced oligonucleotide synthesis. This compound is a critical building block for the development of modified RNA and DNA sequences, offering enhanced stability and specificity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of therapeutic oligonucleotides, antisense therapies, and diagnostic probes.

Application

• Therapeutic Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of antisense oligonucleotides (ASOs) and siRNA.
• Research & Development: Used in academic and industrial labs for studying RNA structure, function, and for developing novel nucleic acid-based tools.
• Diagnostic Probe Manufacturing: Incorporated into fluorescently labeled or otherwise tagged probes for in-situ hybridization and other molecular diagnostic assays.
• Pharmaceutical Intermediates: Serves as a vital intermediate in the production of active pharmaceutical ingredients (APIs) for nucleic acid therapeutics.
• Modified Nucleotide Libraries: Used to create libraries of modified nucleotides for screening and drug discovery platforms.

Basic Information

Product Name	5'-o-(Dimethoxytrityl)-5-Fluoro-O4-(2,4,6-Trimethylphenyl)-2'-o-Methyluridine
CAS No.	869355-47-5
Molecular Formula	C41H41FN2O8
Molecular Weight	708.78 g/mol
Synonyms	5'-O-DMT-5-Fluoro-O4-(2,4,6-trimethylphenyl)-2'-O-methyluridine; 5-Fluoro-2'-O-methyluridine, 5'-O-(4,4'-dimethoxytrityl)-, 4-(2,4,6-trimethylphenyl) ether; 5'-O-(4,4'-Dimethoxytrityl)-5-fluoro-2'-O-methyluridine 4-(2,4,6-trimethylphenyl) ether; 5-Fluoro-2'-O-methyl-5'-O-(4,4'-dimethoxytrityl)uridine, O4-(mesityl) derivative; DMT-5F-O4-Mesityl-2'-O-Me-uridine; 869355-47-5; 5'-DMT-5-Fluoro-O4-(2,4,6-trimethylphenyl)-2'-O-methyluridine
EINECS	Contact for details

Quality Control

Our production of this high-value nucleoside intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and purity for sensitive synthetic applications. Certificates of Analysis (COA) are provided with each shipment, detailing critical parameters such as purity (HPLC), identity (NMR, MS), and moisture content. We operate under a quality management system designed to meet the exacting standards of the pharmaceutical and biotechnology industries.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, cool place. This compound is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions will lead to degradation. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.