Description

5'-o-(Dimethoxytrityl)-5-Fluoro-2'-o-Methyluridine is a sophisticated, high-purity nucleoside derivative designed for advanced oligonucleotide synthesis. This compound serves as a critical building block for the creation of chemically modified RNA strands, offering enhanced stability and specificity. It is an essential raw material for research and development in the pharmaceutical and biotechnology sectors, particularly for applications in antisense oligonucleotide and siRNA therapeutics.

Application

• Solid-Phase Oligonucleotide Synthesis: A key phosphoramidite precursor for the automated synthesis of modified RNA sequences.
• Antisense Therapeutic Development: Used in the research and production of antisense oligonucleotides (ASOs) targeting specific genes.
• siRNA and miRNA Synthesis: Essential for constructing chemically stabilized small interfering RNA (siRNA) and microRNA (miRNA) mimics for gene silencing studies.
• Diagnostic Probe Development: Employed in the manufacture of fluorescently labeled or otherwise tagged nucleic acid probes for diagnostic assays.
• Structural Biology Studies: Used to incorporate 2'-O-methyl and 5-fluoro modifications into RNA for studying structure-function relationships.
• Pharmaceutical Intermediates: Acts as a crucial intermediate in the synthesis of active pharmaceutical ingredients (APIs) for novel RNA-based drugs.

Basic Information

Product Name	5'-o-(Dimethoxytrityl)-5-Fluoro-2'-o-Methyluridine
CAS No.	869355-45-3
Molecular Formula	C31H31FN2O8
Molecular Weight	578.59 g/mol
Synonyms	5'-O-DMT-5-Fluoro-2'-O-methyluridine; 5-Fluoro-2'-O-methyluridine 5'-O-(4,4'-dimethoxytrityl) ether; 5-Fluoro-2'-O-methyl-5'-O-(4,4'-dimethoxytrityl)uridine; 2'-O-Methyl-5-fluorouridine 5'-O-DMT; DMT-5F-2'OMe-U; 5-F-2'-OMe-U DMT; 5-Fluoro-2'-O-methyl-5'-O-DMT-uridine
EINECS	Contact for details

Quality Control

Our 5'-o-(Dimethoxytrityl)-5-Fluoro-2'-o-Methyluridine is manufactured under strict quality control protocols suitable for pharmaceutical research and development. Each batch is analyzed to ensure high purity and consistency, with specifications typically meeting or exceeding industry standards for oligonucleotide synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in acetonitrile, DMF, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.