Description

3-((n-Biotinyl-3-Aminopropoxy(Ethoxy)Ethoxy)Ethoxy)-Propane-1,2-Diol CAS NO 869354-59-6 is a sophisticated, functionalized biotin derivative designed for advanced bioconjugation and molecular labeling applications. This compound is engineered to provide a hydrophilic poly(ethylene glycol) (PEG) spacer arm, enhancing solubility and reducing steric hindrance for efficient coupling to biomolecules. It is primarily utilized by researchers and manufacturers in the pharmaceutical, diagnostic, and life science sectors for developing targeted therapeutics, diagnostic probes, and affinity purification systems.

Application

• Bioconjugation Reagent: For site-specific labeling of proteins, antibodies, and peptides with biotin for detection or purification via streptavidin-biotin interaction.
• Diagnostic Assay Development: Used in the synthesis of probes for ELISA, lateral flow assays, and other immunoassay platforms to enhance sensitivity and specificity.
• Drug Delivery Systems: As a functional component in the design of ligand-targeted drug conjugates and nanoparticles for improved cellular uptake.
• Affinity Chromatography: Immobilization onto solid supports to create resins for the purification of biomolecules.
• Cell Surface Engineering: For labeling cell membrane proteins to study receptor trafficking, cell sorting, and imaging.
• Microarray and Biosensor Fabrication: As a building block for creating functionalized surfaces to capture specific analytes.

Basic Information

Product Name	3-((n-Biotinyl-3-Aminopropoxy(Ethoxy)Ethoxy)Ethoxy)-Propane-1,2-Diol
CAS No.	869354-59-6
Molecular Formula	C26H47N3O9S
Molecular Weight	577.73 g/mol
Synonyms	Biotin-PEG3-Glycerol; Biotin-PEG3-Glycidol; Biotin-(PEG)3-Glycerol; Biotinylated Triethylene Glycol Glycerol Ether; N-Biotinyl-3,6,9-trioxa-12-azatetradecane-1,2,14-triol; 1,2-Propanediol, 3-[2-[2-[2-[[5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino]ethoxy]ethoxy]ethoxy]-; Biotin-PEG3-OH (Glycerol terminated)
EINECS	Contact for details

Quality Control

Our 3-((n-Biotinyl-3-Aminopropoxy(Ethoxy)Ethoxy)Ethoxy)-Propane-1,2-Diol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research and bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. Allow the vial to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90% (by weight)
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, water, methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.