Description

5,8,11,14,17,20,23,26-Octaoxa-2-Azaoctacosanoic Acid, 28-Hydroxy-,9H-Fluoren-9-Ylmethyl Ester is a specialized, high-purity synthetic intermediate featuring a polyether linker and a fluorenylmethyl (Fmoc) protecting group. This compound is critical for researchers and manufacturers requiring precise, high-yield coupling reactions in the synthesis of complex molecules. It is primarily utilized in advanced pharmaceutical research, peptide synthesis, and the development of novel bioconjugates and drug delivery systems.

Application

• Peptide Synthesis: Serves as a key building block for introducing poly(ethylene glycol) (PEG) spacers or hydrophilic linkers into peptide sequences.
• Bioconjugation: Used to create stable linkages between active pharmaceutical ingredients (APIs) and targeting molecules, polymers, or surfaces.
• Pharmaceutical Intermediates: Acts as a crucial intermediate in the multi-step synthesis of complex drug candidates, particularly in oncology and targeted therapies.
• Prodrug Development: Facilitates the design of prodrugs with improved solubility and pharmacokinetic properties via its cleavable Fmoc group.
• Polymer Chemistry: Employed in the synthesis of functionalized polymers and dendrimers for biomedical applications.
• Research & Development: Essential for academic and industrial R&D labs exploring new chemical entities and linker technologies.

Basic Information

Item	Detail
Product Name	5,8,11,14,17,20,23,26-Octaoxa-2-Azaoctacosanoic Acid, 28-Hydroxy-,9H-Fluoren-9-Ylmethyl Ester
CAS No.	868594-51-8
Molecular Formula	C₃₇H₅₅NO₁₁
Molecular Weight	713.83 g/mol
Synonyms	Fmoc-NH-PEG8-CH2CH2COOH; Fmoc-8-amino-3,6-dioxaoctanoic Acid-PEG4-acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-amino-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic Acid; 28-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino-3,6,9,12,15,18,21,24-octaoxaoctacosanoic Acid; Fmoc-PEG8-acid; Fmoc-AEEA-PEG4-acid; Fmoc-N-amido-PEG8-acid
EINECS	Contact for details

Quality Control

Our production of 5,8,11,14,17,20,23,26-Octaoxa-2-Azaoctacosanoic Acid, 28-Hydroxy-,9H-Fluoren-9-Ylmethyl Ester adheres to stringent in-process controls to ensure batch-to-batch consistency and high purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We operate under a quality management system and can supply material suitable for research and cGMP applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; desiccants are recommended for long-term storage. Keep container tightly sealed under an inert atmosphere when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.