Description

Hs-Peg8-Ch2Ch2Cooh CAS NO 866889-02-3 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a thiol-reactive end group and a carboxylic acid terminus. This compound is engineered to serve as a critical linker molecule for bioconjugation, enabling the stable attachment of biomolecules to surfaces, nanoparticles, or other functional entities. It is primarily utilized by researchers and manufacturers in the fields of pharmaceutical development, diagnostic assay production, and advanced material science.

Application

• Bioconjugation and Protein Modification: Acts as a spacer and linker for attaching peptides, proteins, or antibodies to solid supports, quantum dots, or other polymers via its thiol and carboxyl groups.
• Drug Delivery System Development: Used to functionalize liposomes, micelles, and polymeric nanoparticles to enhance solubility, prolong circulation time, and enable targeted delivery of active pharmaceutical ingredients (APIs).
• Surface Functionalization: Employed to create bio-compatible and reactive coatings on biosensor chips, microarray slides, and medical device surfaces.
• Cross-linking Agent: Facilitates the formation of hydrogels or polymer networks for tissue engineering and 3D cell culture scaffolds.
• ADC (Antibody-Drug Conjugate) Linker: Serves as a component in the construction of next-generation ADCs, connecting cytotoxic drugs to monoclonal antibodies.
• PEGylation Reagent: Used to PEGylate therapeutic proteins or small molecules to reduce immunogenicity and improve pharmacokinetic profiles.

Basic Information

Product Name	Hs-Peg8-Ch2Ch2Cooh CAS NO 866889-02-3
CAS No.	866889-02-3
Molecular Formula	C25H48O12S
Molecular Weight	572.7 g/mol
Synonyms	HS-PEG8-COOH; 8-Amino-3,6-dioxaoctyl 17-carboxy-4,7,10,13,16-pentaoxa-2-thiaoctadecan-18-oate; Thiol-PEG8-acid; α-Thiol-ω-carboxy octaethylene glycol; Heterobifunctional PEG, SH-PEG8-COOH; 2,5,8,11,14,17,20,23-Octaoxa-26-thiaoctacosanoic acid; PEG-based heterobifunctional crosslinker
EINECS	Contact for details

Quality Control

Our Hs-Peg8-Ch2Ch2Cooh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance for sensitive bioconjugation applications. Certificates of Analysis (COA) are provided, detailing specifications for purity, functional group integrity, and critical impurities. We support compliance with cGMP and ISO 9001 standards for research and commercial-scale supply.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and maintain stability. The product is hygroscopic; allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight (MS)	572.7 ± 5
Functional Group Assay	≥ 90% (Thiol & Carboxyl)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.