Description

Vernakalant-D6 Hcl is a deuterated isotopologue of the antiarrhythmic agent vernakalant hydrochloride, where six hydrogen atoms are replaced by deuterium. This compound is a critical internal standard used in quantitative bioanalytical methods, ensuring the accuracy and reliability of pharmacokinetic and metabolic studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in the development and quality control of cardiovascular drugs.

Application

• Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the quantification of vernakalant in biological matrices.
• Essential for conducting pharmacokinetic (PK) and bioavailability studies during clinical trials of vernakalant formulations.
• Facilitates drug metabolism and disposition (DMPK) research, aiding in the identification and quantification of metabolites.
• Supports method development and validation in regulatory-compliant bioanalytical laboratories.
• Used in quality control processes for the manufacturing of vernakalant active pharmaceutical ingredient (API) and finished dosage forms.
• Critical for forensic and toxicological analysis where precise measurement of vernakalant is required.

Basic Information

Item	Detail
Product Name	Vernakalant-D6 Hcl
CAS No.	866455-16-5
Molecular Formula	C20H25D6ClN2O3 • HCl
Molecular Weight	409.40 g/mol (approx.)
Synonyms	(1R,2R)-2-[(3R)-1-Pyrrolidinyl]cyclohexanol-D6 Hydrochloride; (3R)-1-[(1R,2R)-2-Hydroxycyclohexyl]pyrrolidine-D6 Hydrochloride; RSD1235-D6; Vernakalant (d6) Hydrochloride; RS 1235-D6; Vernakalant-d6 HCl; Atrial Fibrillation Drug-d6 HCl; RS-D1235-d6 HCl
EINECS	Contact for details

Quality Control

Our Vernakalant-D6 Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for chemical purity and isotopic enrichment, NMR for structural confirmation, and mass spectrometry for identity verification. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes batch-specific data on assay, purity, residual solvents, and heavy metals, ensuring compliance with the stringent requirements of pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.