Description

(1R)-1-(3,4-Dimethoxyphenyl)-4-Hydroxy-2-Cyclohexene-1-Ethanol 1-(4-Methylbenzenesulfonate) is a high-purity chiral intermediate of significant importance in advanced pharmaceutical synthesis. This compound matters because it provides a critical, structurally defined building block for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring stereochemical precision. Pharmaceutical R&D and process chemistry teams need this material for its role in constructing complex molecular architectures, enabling the production of targeted and efficacious drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug molecules, particularly those targeting the central nervous system or cardiovascular diseases.
• Asymmetric Synthesis: Utilized in catalytic or stoichiometric asymmetric reactions to introduce specific stereocenters into advanced lead compounds.
• Process Chemistry & Scale-Up: Serves as a defined starting material or intermediate in the development and optimization of commercial-scale API manufacturing routes.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore new chemical entities and improve pharmacological profiles.
• Reference Standard: Used as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Item	Detail
Product Name	(1R)-1-(3,4-Dimethoxyphenyl)-4-Hydroxy-2-Cyclohexene-1-Ethanol 1-(4-Methylbenzenesulfonate)
CAS No.	866394-50-5
Molecular Formula	C23H28O7S
Molecular Weight	448.53 g/mol
Synonyms	(1R)-1-(3,4-Dimethoxyphenyl)-4-hydroxy-2-cyclohexene-1-ethanol 4-methylbenzenesulfonate; (1R)-1-(3,4-Dimethoxyphenyl)-4-hydroxy-2-cyclohexen-1-yl-ethanol p-toluenesulfonate; (1R)-1-(3,4-Dimethoxyphenyl)-4-hydroxy-2-cyclohexene-1-ethyl p-tosylate; (1R)-4-Hydroxy-1-(3,4-dimethoxyphenyl)-2-cyclohexene-1-ethanol 1-tosylate; Phenylcyclohexene derivative tosylate; Chiral cyclohexenol tosylate intermediate
EINECS	Contact for details

Quality Control

Our (1R)-1-(3,4-Dimethoxyphenyl)-4-Hydroxy-2-Cyclohexene-1-Ethanol 1-(4-Methylbenzenesulfonate) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical R&D. All products undergo rigorous analytical testing, including HPLC, NMR, and chiral purity analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.