Description

Propanoic Acid, 2-Methyl-, 1-[[[(2,5-Dioxo-1-Pyrrolidinyl)Oxy]Carbonyl]Oxy]Ethyl Ester is a specialized active ester derivative of isobutyric acid, designed for high-performance conjugation chemistry. This compound matters for its role as a versatile and efficient reagent for introducing the isobutyryl moiety into target molecules, particularly in peptide and protein modification. It is primarily needed by research and development laboratories in the pharmaceutical and biotech sectors, as well as by manufacturers of advanced polymers and specialty fine chemicals seeking reliable and pure synthetic intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and prodrugs requiring isobutyric acid functionalization.
• Bioconjugation Reagent: Used for the selective modification of peptides, proteins, and antibodies, enabling the attachment of labels, drugs, or polymers.
• Polymer Chemistry: Serves as a monomer or cross-linking agent in the production of specialty polyesters and functional polymeric materials.
• Proteomics Research: Employed in chemical proteomics for activity-based protein profiling (ABPP) and target identification studies.
• Linker Chemistry: Functions as a cleavable or stable linker in solid-phase synthesis and the development of drug delivery systems.
• Fine Chemical Synthesis: A critical reagent for organic chemists in academia and industry for constructing complex molecules with specific ester functionalities.

Basic Information

Item	Detail
Product Name	Propanoic Acid, 2-Methyl-, 1-[[[(2,5-Dioxo-1-Pyrrolidinyl)Oxy]Carbonyl]Oxy]Ethyl Ester
CAS No.	860035-10-5
Molecular Formula	C11H15NO7
Molecular Weight	273.24 g/mol
Synonyms	1-[[[(2,5-Dioxo-1-pyrrolidinyl)oxy]carbonyl]oxy]ethyl 2-methylpropanoate; 2,5-Dioxopyrrolidin-1-yl (1-isobutyryloxyethoxy)formate; Isobutyric Acid Active Ester; N-Hydroxysuccinimide (NHS) Ester of Isobutyric Acid O-Carbonate; Isobutyryloxyethyl Carbonate NHS Ester; (1-(((2,5-Dioxopyrrolidin-1-yl)oxy)carbonyl)oxy)ethyl isobutyrate; Active Isobutyrate Ester; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Every batch of our Propanoic Acid, 2-Methyl-, 1-[[[(2,5-Dioxo-1-Pyrrolidinyl)Oxy]Carbonyl]Oxy]Ethyl Ester is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive conjugation and synthesis applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by HPLC, NMR, and other relevant techniques.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C (refrigerated) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or moisture will compromise stability and reactivity. Keep container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.