Description

Bis-Mal-Dpeg(R)11 CAS NO 854753-78-9 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a maleimide group and a protected maleimide group, separated by a PEG spacer of defined molecular weight. This compound is a critical reagent for the site-specific conjugation of biomolecules, enabling the creation of stable, homogeneous bioconjugates for advanced therapeutic and diagnostic applications. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for developing antibody-drug conjugates (ADCs), protein-polymer conjugates, and other sophisticated drug delivery systems.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a key heterobifunctional crosslinker for connecting cytotoxic drugs to monoclonal antibodies, enabling targeted cancer therapy.
• Protein and Peptide PEGylation: Used for the site-specific modification of proteins and peptides to enhance solubility, prolong circulation half-life, and reduce immunogenicity.
• Diagnostic Probe Conjugation: Facilitates the attachment of imaging agents (e.g., fluorophores, radiolabels) to targeting molecules like antibodies or peptides for in vitro and in vivo diagnostics.
• Nanoparticle Functionalization: Employed to modify the surface of liposomes, polymeric nanoparticles, or other nanocarriers with targeting ligands for improved drug delivery.
• Biomaterial Surface Modification: Used to create biofunctional surfaces on scaffolds and implants by conjugating bioactive peptides or proteins.
• Enzyme Immobilization: Aids in the controlled immobilization of enzymes onto solid supports for biocatalysis and biosensor applications.

Basic Information

Product Name	Bis-Mal-Dpeg(R)11
CAS No.	854753-78-9
Molecular Formula	C58H96N2O28
Molecular Weight	~1269.4 g/mol
Synonyms	1,1'-(11,11'-Dioxo-3,6,9-trioxa-10,11-diazaheptadecane-1,17-diyl)bis(1H-pyrrole-2,5-dione); Maleimide-PEG11-Maleimide (Protected); Bis-Maleimide-PEG11 (one protected); α-Maleimide-ω-(protected maleimide)-undecaethylene glycol; Heterobifunctional PEG11 Maleimide Crosslinker; Bis-Mal-PEG11; BM(PEG)11
EINECS	Contact for details

Quality Control

Our Bis-Mal-Dpeg(R)11 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for bioconjugation research and cGMP manufacturing support. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay	≥ 90% (Maleimide & Protected Maleimide)
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.