Description

1,2-Dioctanoyl-Sn-Glycero-3-Phospho-(1'-Myo-Inositol-4',5'-Bisphosphate) (Ammonium Salt) is a high-purity, synthetic phospholipid derivative of phosphatidylinositol 4,5-bisphosphate (PIP2), a critical signaling molecule in cellular processes. This compound is essential for biochemical research, particularly in studying membrane dynamics, signal transduction pathways, and lipid-protein interactions. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in advanced cell biology, neuroscience, and drug discovery programs.

Application

• Biochemical Research Reagent: A critical tool for in vitro studies of phosphoinositide signaling cascades, including PLC (phospholipase C) and PI3K (phosphoinositide 3-kinase) pathways.
• Lipid Kinase/Phosphatase Substrate: Used as a defined substrate for enzymatic assays to study the activity and inhibition of lipid-modifying enzymes.
• Membrane Biophysics: Employed in the formation of model membranes (liposomes, supported lipid bilayers) to investigate protein-lipid binding and membrane recruitment.
• Drug Discovery Screening: Serves as a target component in high-throughput screening assays to identify novel therapeutics targeting lipid signaling disorders.
• Neuroscience Research: Applied in studies of synaptic vesicle trafficking, ion channel regulation, and other neuronal functions modulated by phosphoinositides.
• Cell Signaling Studies: Used to reconstitute cellular signaling events in cell-free systems or to deliver specific lipids into live cells.
• Reference Standard: Acts as a high-purity analytical standard for lipidomics and mass spectrometry-based identification and quantification.

Basic Information

Product Name	1,2-Dioctanoyl-Sn-Glycero-3-Phospho-(1'-Myo-Inositol-4',5'-Bisphosphate) (Ammonium Salt)
CAS No.	852043-37-9
Molecular Formula	C29H59N2O19P3
Molecular Weight	832.73 g/mol
Synonyms	PI(4,5)P2 (C8); DiC8 PI(4,5)P2; 1,2-Di-O-octanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) ammonium salt; Phosphatidylinositol 4,5-bisphosphate (C8:0); PIP2 (C8); PtdIns(4,5)P2 (diC8); Ammonium 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)
EINECS	Contact for details

Quality Control

Our 1,2-Dioctanoyl-Sn-Glycero-3-Phospho-(1'-Myo-Inositol-4',5'-Bisphosphate) (Ammonium Salt) is manufactured under strict quality protocols suitable for research applications. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay (by HPLC), identity (by NMR/MS), and impurity profiles are provided to guarantee the material meets the stringent requirements of life science research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Assay (HPLC)	≥ 95%
Solubility	Soluble in chloroform/methanol/water mixtures

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.