Description

1,2-Dioctanoyl-Sn-Glycero-3-Phospho-(1'-Myo-Inositol-3',5'-Bisphosphate) (Ammonium Salt) is a high-purity, synthetic phospholipid derivative, specifically a phosphatidylinositol bisphosphate (PIP2) analog with defined acyl chains. This compound is a critical biochemical tool for studying intracellular signaling pathways, particularly those involving phosphoinositide metabolism and membrane trafficking. It is essential for researchers and developers in pharmaceutical discovery, cell biology, and biochemical assay development who require precise and reliable lipid standards and substrates.

Application

• Biochemical Research: As a substrate for enzymes like phospholipase C (PLC) and phosphoinositide 3-kinases (PI3Ks) to study inositol phosphate signaling cascades.
• Lipidomics & Analytical Standards: Used as a high-purity reference standard in mass spectrometry (LC-MS/MS) for the identification and quantification of complex lipids in biological samples.
• Drug Discovery Screening: Incorporated into assay platforms to identify and characterize inhibitors or activators of phosphoinositide-metabolizing enzymes, a key target class in oncology and metabolic diseases.
• Membrane Biophysics: For the reconstitution of lipid bilayers and liposomes to investigate protein-lipid interactions and membrane dynamics.
• Cell Signaling Studies: Used in cellular delivery systems (e.g., via carriers) to directly modulate intracellular PIP2 levels and observe downstream effects.

Basic Information

Product Name	1,2-Dioctanoyl-Sn-Glycero-3-Phospho-(1'-Myo-Inositol-3',5'-Bisphosphate) (Ammonium Salt)
CAS No.	852043-36-8
Molecular Formula	C29H59N2O19P3
Molecular Weight	832.75 g/mol
Synonyms	PI(3,5)P2 (C8); PI(3,5)P2 (diC8); 1,2-Di-O-octanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) ammonium salt; Phosphatidylinositol 3,5-bisphosphate (C8); PtdIns(3,5)P2 diC8; DiC8-PI(3,5)P2; Ammonium 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol 3,5-bisphosphate)
EINECS	Contact for details

Quality Control

This high-value biochemical is manufactured under strict quality protocols to ensure exceptional purity and batch-to-batch consistency. Each lot is characterized by advanced analytical techniques including NMR and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (P)	≥ 98% (on anhydrous basis)
Solubility	Soluble in chloroform/methanol/water mixtures

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.