Description

1,2-Dioctanoyl-Sn-Glycero-3-Phospho-(1'-Myo-Inositol-3',4'-Bisphosphate) (Ammonium Salt) is a high-purity, synthetic phospholipid derivative, specifically a diacylglycerol phosphoinositol polyphosphate, essential for advanced biochemical and pharmaceutical research. This compound serves as a critical tool for studying intracellular signaling pathways, particularly those involving phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] and its role in cell growth, proliferation, and membrane trafficking. It is primarily utilized by research scientists and product developers in academic institutions, pharmaceutical R&D, and biotechnology companies focused on lipidomics, signal transduction, and drug discovery.

Application

• Biochemical Research Reagent: Used as a substrate or standard in enzymatic assays to study the activity of kinases, phosphatases, and phospholipases involved in phosphoinositide metabolism.
• Lipidomics & Mass Spectrometry: Serves as a critical internal standard or reference compound for the qualitative and quantitative analysis of complex lipid samples via LC-MS/MS.
• Cell Signaling Studies: Applied in cell-based assays to investigate the specific roles of PI(3,4)P2 in cellular processes such as endocytosis, cytoskeletal reorganization, and Akt signaling.
• Liposome & Drug Delivery System Formulation: Incorporated into lipid nanoparticles (LNPs) or liposomal membranes to modulate surface charge and study membrane-protein interactions.
• Pharmaceutical Development: Employed in high-throughput screening (HTS) campaigns to identify novel inhibitors or activators of phosphoinositide 3-kinase (PI3K) related pathways.
• Diagnostic Kit Development: Used in the development of ELISA or other immunoassays for detecting and quantifying specific phosphoinositides or related antibodies.

Basic Information

Product Name	1,2-Dioctanoyl-Sn-Glycero-3-Phospho-(1'-Myo-Inositol-3',4'-Bisphosphate) (Ammonium Salt)
CAS No.	852043-35-7
Molecular Formula	C29H57N2O19P3
Molecular Weight	854.73 g/mol
Synonyms	PI(3,4)P2 (C8:0); 1,2-Di-O-octanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) ammonium salt; Dioctanoyl PI(3,4)P2; 3,4-Bisphospho-D-myo-inositol 1-(1,2-di-O-octanoyl-sn-glycero-3-phosphate) ammonium salt; Ammonium 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol 3,4-bisphosphate); Dipalmitoyl PI(3,4)P2 analog (C8); Synthetic Phosphatidylinositol 3,4-bisphosphate; L-α-Phosphatidylinositol-3,4-bisphosphate (C8:0)
EINECS	Contact for details

Quality Control

Every batch of our high-purity phospholipids is manufactured and analyzed under strict quality protocols. We guarantee identity, purity, and consistency through a comprehensive suite of analytical techniques including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters such as assay purity, impurity profile, and solvent residues to ensure compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Assay (HPLC)	≥ 95%
Solvent Content (Residual Solvents)	Meets ICH guidelines
Water Content (KF)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.