Description

(2-Pyridyldithio)-Peg4-Alcohol is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a reactive pyridyl disulfide (PDS) group and a terminal hydroxyl group. This compound is essential for creating stable, cleavable conjugates in bioconjugation and nanotechnology, enabling the controlled attachment and release of biomolecules. It is primarily needed by researchers and manufacturers in the fields of biopharmaceutical development, diagnostic assay production, and advanced material science.

Application

• Bioconjugation Reagent: For site-specific conjugation of peptides, proteins, or antibodies via thiol-disulfide exchange, forming cleavable linkages.
• Drug Delivery Systems: As a functional linker in the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutic nanoparticles.
• Surface Functionalization: To modify gold nanoparticles, quantum dots, or other surfaces with a hydrophilic PEG spacer and a reactive handle for further coupling.
• Crosslinking Agent: In hydrogel formation and polymer chemistry where a reducible, stimuli-responsive crosslink is required.
• Diagnostic Probe Development: For attaching reporter molecules (e.g., fluorophores, enzymes) to targeting moieties in assay components.
• Protein PEGylation: To introduce a PEG chain onto specific cysteine residues, modulating pharmacokinetics and stability.

Basic Information

Product Name	(2-Pyridyldithio)-Peg4-Alcohol
CAS No.	851961-99-4
Molecular Formula	C19H31NO7S2
Molecular Weight	449.58 g/mol
Synonyms	2-Pyridyldithio tetraethyleneglycol alcohol; PDS-PEG4-OH; 2-(2-Pyridyldithio)ethoxyethoxyethoxyethoxyethanol; SS-PEG4-OH; Pyridyl disulfide PEG4 alcohol; Heterobifunctional PEG crosslinker, PDS-PEG4-OH; 19-Aza-3,6,9,12,15-pentaoxa-18-thia-20-thioneicosan-21-ol, 2-(2-pyridinyldithio)ethyl ether; 2,5,8,11,14-Pentaoxa-17-thia-19-azahenicosane-18,21-dithione, 21-hydroxy-
EINECS	Contact for details

Quality Control

Our (2-Pyridyldithio)-Peg4-Alcohol is manufactured under strict quality protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the high standards required for research and bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.