Description

(2,5-Dioxopyrrolidin-1-Yl) 11-Azidoundecanoate is a heterobifunctional crosslinking reagent featuring an amine-reactive N-hydroxysuccinimide (NHS) ester and an azide group for copper-free click chemistry. This compound is essential for creating stable, covalent linkages between biomolecules, enabling advanced bioconjugation strategies without the need for cytotoxic catalysts. It is primarily needed by researchers and manufacturers in the fields of biopharmaceutical development, proteomics, and materials science for applications such as antibody-drug conjugate (ADC) synthesis, protein labeling, and surface functionalization.

Application

• Bioconjugation and ADC Development: A key reagent for site-specific conjugation of cytotoxic payloads to monoclonal antibodies, creating next-generation antibody-drug conjugates.
• Protein and Peptide Labeling: Facilitates the attachment of fluorescent dyes, affinity tags (e.g., biotin), or other probes to proteins via stable amide bonds and subsequent click chemistry.
• Polymer and Biomaterial Functionalization: Used to modify surfaces, hydrogels, and nanoparticles with bioactive ligands or to create crosslinked networks for tissue engineering and drug delivery systems.
• Chemical Biology Probes: Enables the synthesis of activity-based probes for studying enzyme function and protein-protein interactions in living systems.
• Diagnostic Assay Development: Employed in the fabrication of sensitive immunoassays and biosensors by immobilizing capture antibodies or antigens on solid supports.
• Glycan and Carbohydrate Chemistry: Useful for labeling and conjugating complex sugars for glycomics research and vaccine development.

Basic Information

Product Name	(2,5-Dioxopyrrolidin-1-Yl) 11-Azidoundecanoate
CAS No.	850080-13-6
Molecular Formula	C₁₇H₂₈N₄O₄
Molecular Weight	352.43 g/mol
Synonyms	11-Azidoundecanoic Acid N-Hydroxysuccinimide Ester; NHS-11-Azidoundecanoate; Azido-PEG11-NHS Ester; N-Succinimidyl 11-Azidoundecanoate; 11-Azidoundecanoic Acid Succinimidyl Ester; Azido-C11-NHS; N-(11-Azidoundecanoyloxy)succinimide; Heterobifunctional Crosslinker, NHS-Azide
EINECS	Contact for details

Quality Control

Our (2,5-Dioxopyrrolidin-1-Yl) 11-Azidoundecanoate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC purity analysis, NMR structural confirmation, and mass spectrometry verification. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake. For long-term stability, store under inert atmosphere (argon or nitrogen).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.