Description

17α-Hydroxyprogesterone-D8 (2,2,4,6,6,21,21,21-D8) is a high-purity, deuterium-labeled analog of the endogenous steroid hormone 17α-Hydroxyprogesterone. This stable isotope-labeled compound is an essential reference standard and internal standard for precise analytical quantification in complex biological matrices. It is primarily required by pharmaceutical R&D laboratories, clinical research organizations, and diagnostic manufacturers for method development and validation in mass spectrometry-based assays.

Application

• Internal Standard for LC-MS/MS: Critical for the accurate quantification of endogenous 17α-Hydroxyprogesterone in clinical and research bioanalysis, correcting for matrix effects and instrument variability.
• Metabolic Pathway Studies: Used as a tracer in steroidogenesis research to investigate biosynthesis and metabolic pathways of progestogens and corticosteroids.
• Diagnostic Assay Development: A key component in the development and calibration of high-sensitivity diagnostic kits for conditions like congenital adrenal hyperplasia (CAH).
• Pharmaceutical Quality Control: Serves as a reference standard for the analysis of steroid-based pharmaceutical products and raw materials.
• Forensic & Doping Control: Employed in confirmatory testing for endogenous steroid profiling in anti-doping and forensic toxicology laboratories.
• Biomarker Research: Facilitates reliable measurement of 17α-Hydroxyprogesterone as a biomarker in endocrinology and oncology studies.

Basic Information

Item	Details
Product Name	17α-Hydroxyprogesterone-D8 (2,2,4,6,6,21,21,21-D8)
CAS No.	850023-80-2
Molecular Formula	C21H22D8O3
Molecular Weight	338.50 g/mol (approx.)
Synonyms	17α-Hydroxy-4-pregnene-3,20-dione-d8; 17-OHP-d8; 17α-Hydroxyprogesterone (2,2,4,6,6,21,21,21-d8); 17α-Hydroxypregn-4-ene-3,20-dione-d8; Deuterated 17α-Hydroxyprogesterone; 17α-Hydroxyprogesterone (D8); 17α-OHP-d8; 17α-Hydroxyprogesterone-2,2,4,6,6,21,21,21-d8
EINECS	Contact for details

Quality Control

Every batch of our 17α-Hydroxyprogesterone-D8 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity to meet the exacting demands of analytical reference standard applications. Certificates of Analysis (COA) are provided with each shipment, detailing comprehensive analytical results from techniques including HPLC, NMR, and Mass Spectrometry. Our quality commitment ensures reliable and reproducible performance in your most sensitive assays.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.