Description

4-Arm-Peg-Cooh CAS NO 848779-31-7 is a multi-arm polyethylene glycol derivative functionalized with carboxylic acid end groups. This branched, hydrophilic polymer is a critical building block for creating advanced, multi-functional materials with tailored properties. It is essential for researchers and manufacturers in the pharmaceutical, biomedical, and advanced materials sectors who require precise control over molecular architecture and surface chemistry for applications like drug delivery systems, hydrogels, and bioconjugation.

Application

• Drug Delivery Systems: Serves as a core scaffold for constructing multi-arm, star-shaped polymeric micelles or nanoparticles for controlled and targeted drug release.
• Hydrogel Formation: Acts as a multi-functional crosslinker or precursor for creating biocompatible and tunable hydrogels used in tissue engineering and wound healing.
• Bioconjugation & Protein Modification: The carboxylic acid arms provide sites for covalent attachment to biomolecules (e.g., peptides, proteins, antibodies) via amide bond formation, enabling PEGylation to improve stability and pharmacokinetics.
• Surface Functionalization: Used to modify material surfaces (e.g., nanoparticles, medical devices) to introduce carboxyl groups, enhancing hydrophilicity and providing anchor points for further chemical grafting.
• Dendrimer & Polymer Synthesis: Functions as a versatile core molecule for the synthesis of complex dendritic or hyperbranched polymers with high functional group density.
• Diagnostic Reagents: Employed in the development of diagnostic assays and imaging agents where multiple labeling sites are required on a single, water-soluble platform.

Basic Information

Item	Detail
Product Name	4-Arm-Peg-Cooh
CAS No.	848779-31-7
Molecular Formula	C(4n+4)H(8n+8)O(n+5) *
Molecular Weight	Variable (based on PEG arm length, e.g., 2k, 5k, 10k Da)
Synonyms	4-Arm PEG Acid; 4-Arm PEG Carboxylic Acid; Tetra-Arm PEG COOH; Tetrabranched PEG Carboxylate; Poly(ethylene glycol) tetracarboxylic acid; PEG4-(COOH)4; Star-PEG-(COOH)4; 4-Arm Poly(ethylene glycol) Terminated with Carboxyl Groups
EINECS	Contact for details

* Formula is representative; 'n' denotes the number of ethylene oxide units per arm.

Quality Control

Our 4-Arm-Peg-Cooh is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including NMR for structural confirmation, GPC/SEC for molecular weight distribution, and titration for functional group quantification, to ensure consistency and purity. Certificates of Analysis (COA) documenting all specifications are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic nature, store in a cool, dry place (recommended 2-8°C or as specified on the label) under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (NMR)	Complies with structure
Molecular Weight (Average)	As per ordered grade (e.g., 2,000 Da, 5,000 Da, 10,000 Da)
Polydispersity Index (PDI) by GPC	≤ 1.10
Assay (COOH Content)	≥ 95% (by titration)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.