Description

(6S)-Hydroxy (S,S)-Palonosetron is a key chiral intermediate and stereoisomer in the synthesis of advanced pharmaceutical compounds. This high-purity building block is critical for ensuring the precise stereochemistry required in the production of potent and selective active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development and scale-up of novel therapeutics, particularly in the areas of oncology and antiemetic drug formulations. The compound's defined stereochemistry is essential for achieving desired pharmacological activity and minimizing off-target effects.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the multi-step synthesis of Palonosetron hydrochloride and related 5-HT3 receptor antagonists.
• Process Research & Development (R&D): Used in route scouting and optimization studies for the efficient and stereoselective manufacturing of complex drug molecules.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling of final drug substances.
• Active Pharmaceutical Ingredient (API) Synthesis: A key precursor in the production of high-purity APIs targeting chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV).
• Asymmetric Synthesis: Utilized in studies exploring novel catalytic asymmetric reactions due to its defined stereogenic centers.
• Metabolite Studies: Investigated as a potential metabolite or for the synthesis of labeled analogs in pharmacokinetic and drug metabolism research.

Basic Information

Item	Details
Product Name	(6S)-Hydroxy (S,S)-Palonosetron
CAS No.	848074-08-8
Molecular Formula	C19H24N2O
Molecular Weight	296.41 g/mol
Synonyms	(3aS)-2-[(3S)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one; (S,S)-Palonosetron Intermediate; (6S)-Hydroxy Palonosetron; Palonosetron (S,S)-Isomer; UNII-6M9P6KZ6NN (component); (3aS)-2-[(3S)-2-Azabicyclo[2.2.2]oct-3-yl]-1,2,3,3a,4,5-hexahydrobenz[de]isoquinolin-1-one; (S)-Palonosetron Alcohol Derivative
EINECS	Contact for details

Quality Control

Our (6S)-Hydroxy (S,S)-Palonosetron is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to support regulatory filings (e.g., DMF, CMC sections). We adhere to cGMP principles where applicable to ensure supply chain integrity and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation. For long-term storage, consider inert atmosphere packaging to maximize stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.