Description

Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg-Nh2 is a synthetic, fluorogenic peptide substrate designed for highly sensitive enzymatic assays. This compound is critical for researchers and quality control laboratories requiring precise detection and quantification of specific protease activity. It is primarily utilized in pharmaceutical R&D, biochemical research, and diagnostic kit development for studying enzyme kinetics and inhibitor screening.

Application

• Protease Activity Assays: As a selective fluorogenic substrate for monitoring the activity of specific proteases like cathepsins or related enzymes in real-time.
• High-Throughput Screening (HTS): Used in drug discovery platforms to identify and characterize novel protease inhibitors for therapeutic targets.
• Biochemical Research: A key tool for investigating enzyme mechanisms, substrate specificity, and kinetic parameters in purified systems.
• Diagnostic Development: Serves as a core component in the development of sensitive diagnostic assays for diseases linked to abnormal protease activity.
• Quality Control in Biologics: Employed in QC labs to test for the presence and activity of specific enzymes in biopharmaceutical products.

Basic Information

Product Name	Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg-Nh2
CAS No.	839730-93-7
Molecular Formula	C86H128N24O17
Molecular Weight	1762.1 g/mol
Synonyms	Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg-NH2; (7-Methoxycoumarin-4-yl)acetyl-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(2,4-Dinitrophenyl)-D-Arg-amide; Fluorogenic Peptide Substrate Mca-Peptide-Dnp; Cathepsin Fluorogenic Substrate; Mca-Peptide-Dnp; Protease Substrate 839730-93-7; Dnp-Labeled Peptide Substrate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and performance in standardized assay conditions. We adhere to strict quality management protocols to guarantee batch-to-batch consistency for research and diagnostic applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 70%
Solubility	Soluble in DMSO, DMF
Functional Activity	Conforms to reference standard

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.