Description

Tropisetron Mesylate CAS NO 833482-77-2 is the mesylate salt form of Tropisetron, a potent and selective 5-HT3 receptor antagonist. This high-purity pharmaceutical intermediate is critical for the synthesis of antiemetic medications used to prevent nausea and vomiting, particularly following chemotherapy or surgery. It is an essential raw material for pharmaceutical manufacturers and research institutions developing and producing advanced therapeutic formulations.

Application

• Primary Pharmaceutical Ingredient: Key active pharmaceutical intermediate for the manufacture of finished dosage forms of Tropisetron.
• Antiemetic Drug Synthesis: Used in the production of medications to prevent and treat chemotherapy-induced nausea and vomiting (CINV) and post-operative nausea and vomiting (PONV).
• Research & Development: Serves as a critical reference standard and building block in pharmacological research and new drug development programs targeting serotonin receptors.
• Formulation Development: Employed in the development of various drug delivery systems, including injectables and oral formulations.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP-compliant production of therapeutic agents.

Basic Information

Product Name	Tropisetron Mesylate
CAS No.	833482-77-2
Molecular Formula	C17H20N2O2 • CH4O3S
Molecular Weight	380.46 g/mol
Synonyms	Tropisetron Methanesulfonate; Tropisetron Mesilate; ICS 205-930 Mesylate; (1αH,3α,5αH)-Tropan-3-yl 1H-Indole-3-carboxylate Methanesulfonate; Navoban (brand name salt form); Indol-3-carboxylic acid (1αH,3α,5αH)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester methanesulfonate
EINECS	Contact for details

Quality Control

Our Tropisetron Mesylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided, confirming identity, purity, and impurity profiles as per in-house specifications aligned with ICH guidelines. We support our partners with the documentation necessary for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.