Description

Docosahexaenoyl Coenzyme A (Ammonium Salt) is a high-purity, biologically active coenzyme A derivative of the essential ω-3 fatty acid DHA (docosahexaenoic acid). This compound serves as a critical substrate in enzymatic research, particularly for studying lipid metabolism, biosynthesis, and signaling pathways. It is essential for researchers and developers in pharmaceutical discovery, biochemical research, and nutraceutical development who require precise tools for investigating the role of DHA at the molecular level.

Application

• Enzymology & Metabolic Research: As a specific substrate for acyl-CoA synthetases, desaturases, and elongases in studies of fatty acid metabolism and the biosynthesis of complex lipids.
• Lipidomics & Analytical Standards: Used as a reference standard in mass spectrometry (LC-MS/MS) for the identification and quantification of DHA-containing lipid species in biological samples.
• Cell Signaling Studies: Investigation of the role of DHA-CoA in cellular processes, including gene regulation, membrane remodeling, and the production of lipid mediators.
• Pharmaceutical Development: Tool compound in high-throughput screening (HTS) assays to identify modulators of enzymes involved in DHA metabolism for therapeutic targeting.
• Biochemical Reagent: Essential reagent for in vitro reconstitution of metabolic pathways and for studying enzyme kinetics and specificity.

Basic Information

Product Name	Docosahexaenoyl Coenzyme A (Ammonium Salt)
CAS No.	800377-20-2
Molecular Formula	C43H74N7O17P3S • xNH3
Molecular Weight	~1126.0 g/mol (free acid)
Synonyms	DHA-CoA; Docosahexaenoyl-CoA; all-cis-4,7,10,13,16,19-Docosahexaenoyl-Coenzyme A ammonium salt; Coenzyme A, S-(all-Z)-docosa-4,7,10,13,16,19-hexaenoate; 22:6(n-3) CoA; (4Z,7Z,10Z,13Z,16Z,19Z)-Docosa-4,7,10,13,16,19-hexaenoyl-coenzyme A ammonium salt
EINECS	Contact for details

Quality Control

Our Docosahexaenoyl Coenzyme A (Ammonium Salt) is manufactured under controlled conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) detailing all specifications, ensuring the material meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This material is hygroscopic (moisture-sensitive) and easily oxidized; avoid repeated freeze-thaw cycles and exposure to air. For long-term storage, keep desiccated at -80°C.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in water, methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.