Description

2-Amino-5,8-Dihydro-6-(3-Hydroxy-1,2-Dimercapto-4-Phosphonooxy-1-Butenyl)-4(1H)-Pteridinone is a complex, high-purity pteridine derivative of significant interest in advanced biochemical research and pharmaceutical development. This compound matters for its unique structural features, including a phosphonooxy group and dimercapto moiety, which make it a valuable intermediate for synthesizing novel enzyme inhibitors and potential therapeutic agents. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on nucleotide metabolism, redox biology, and targeted drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel pterin-based drug candidates targeting specific enzymatic pathways.
• Biochemical Research: Used as a reference standard or probe in studies of folate metabolism, redox cofactors, and one-carbon transfer reactions.
• Enzyme Inhibition Studies: Investigated for its potential as an inhibitor of dihydrofolate reductase (DHFR) and other pteridine-dependent enzymes.
• Precursor for Labeled Compounds: Acts as a starting material for the synthesis of isotopically labeled (e.g., 13C, 15N) compounds for metabolic tracing and pharmacokinetic studies.
• Ligand for Metal Complexation: Its dimercapto and phosphonooxy groups make it a candidate for chelating specific metal ions in catalytic or diagnostic applications.
• Development of Diagnostic Reagents: Potential use in developing assays or sensors related to cellular redox status or specific metabolite detection.

Basic Information

Product Name	2-Amino-5,8-Dihydro-6-(3-Hydroxy-1,2-Dimercapto-4-Phosphonooxy-1-Butenyl)-4(1H)-Pteridinone
CAS No.	89700-34-5
Molecular Formula	C10H14N5O7PS2
Molecular Weight	403.35 g/mol
Synonyms	6-(3-Hydroxy-1,2-dimercapto-4-phosphonooxy-1-butenyl)-2-amino-5,8-dihydro-4(1H)-pteridinone; 2-Amino-4-oxo-5,8-dihydro-6-[(3-hydroxy-1,2-dimercapto-4-phosphonooxy)-1-butenyl]pteridine; Phosphonooxy-Dimercapto Pteridinone Derivative; Pteridine phosphorothioate intermediate; CAS 89700-34-5
EINECS	Contact for details

Quality Control

Our 2-Amino-5,8-Dihydro-6-(3-Hydroxy-1,2-Dimercapto-4-Phosphonooxy-1-Butenyl)-4(1H)-Pteridinone is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. The material is hygroscopic and moisture-sensitive; ensure the container is sealed in a dry environment before opening. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.