Description

Tropisetron-001 CAS NO 89565-91-3 is a high-purity pharmaceutical intermediate and active ingredient belonging to the class of serotonin 5-HT₃ receptor antagonists. Its primary value lies in its critical role as a precursor in the synthesis of antiemetic medications used to prevent nausea and vomiting, particularly following chemotherapy or surgery. This compound is essential for manufacturers in the pharmaceutical and fine chemical industries engaged in the production of advanced therapeutic agents.

Application

• Pharmaceutical Synthesis: Key intermediate in the manufacture of the antiemetic drug Tropisetron hydrochloride.
• Active Pharmaceutical Ingredient (API) Production: Serves as a core building block for finished dosage forms in oncology and post-operative care.
• Research & Development: Used in biochemical and pharmacological research to study 5-HT₃ receptor mechanisms and develop new therapeutic candidates.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Fine Chemical Manufacturing: Utilized in the synthesis of more complex, specialized chemical entities for medical applications.

Basic Information

Product Name	Tropisetron-001
CAS No.	89565-91-3
Molecular Formula	C₁₇H₂₀N₂O₂
Molecular Weight	284.35 g/mol
Synonyms	Tropisetron; ICS 205-930; (1αH,3αH,5αH)-Tropan-3-yl 1H-indole-3-carboxylate; 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 1H-indole-3-carboxylate; Navoban (brand name precursor); Indole-3-carboxylic acid tropan-3-yl ester
EINECS	Contact for details

Quality Control

Our Tropisetron-001 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. Quality is verified through comprehensive analytical testing, including HPLC for assay and related substances, residual solvent analysis, and identification tests. A Certificate of Analysis (COA) detailing all specifications and results is provided with each shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.