Description

n-Methyl-(R)-Valine Benzyl Ester is a chiral, non-proteinogenic amino acid derivative of significant synthetic utility. This compound serves as a crucial building block in the synthesis of complex molecules, particularly in the pharmaceutical sector. It is primarily utilized by research institutions and manufacturers engaged in the development of peptidomimetics, active pharmaceutical ingredients (APIs), and other fine chemicals requiring high stereochemical purity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of peptide-based drugs and protease inhibitors.
• Peptidomimetic Research: Used to introduce the n-methylated valine moiety into peptide backbones to enhance metabolic stability and membrane permeability.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in stereoselective chemical transformations.
• API Development: Serves as a critical raw material in the production route for various active pharmaceutical ingredients.
• Biochemical Research: Utilized in studies exploring enzyme-substrate interactions and structure-activity relationships (SAR).
• Fine Chemical Synthesis: A versatile intermediate for creating custom-designed, high-value specialty chemicals.

Basic Information

Product Name	n-Methyl-(R)-Valine Benzyl Ester
CAS No.	89536-87-8
Molecular Formula	C13H19NO2
Molecular Weight	221.30 g/mol
Synonyms	(R)-2-(Methylamino)-3-methylbutanoic acid benzyl ester; Benzyl (R)-2-(methylamino)-3-methylbutanoate; (R)-N-Methylvaline benzyl ester; D-N-Methylvaline O-benzyl ester; (R)-N-Methylvaline O-benzyl ester; N-Me-D-Val-OBzl; N-Methyl-D-valine benzyl ester; Benzyl N-methyl-D-valinate
EINECS	Contact for details

Quality Control

Our n-Methyl-(R)-Valine Benzyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. We provide comprehensive Certificates of Analysis (COA) for each lot, detailing key parameters such as chiral purity, chemical assay, and impurity profiles. Our quality systems are designed to meet the stringent requirements of GMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product is hygroscopic (moisture-sensitive); ensure containers are sealed after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.