Description

2-Acetyl-S-Octadecyl-1-Thioglycero-3-Phosphocholine is a specialized synthetic phospholipid derivative, notable for its unique acetylated thioether linkage. This compound is critical for advanced research and development in lipid-based drug delivery systems, where its structural properties enable precise control over vesicle formation and stability. It is primarily sought by pharmaceutical researchers, formulation scientists, and manufacturers in the life sciences sector for creating next-generation liposomal and nanoparticle therapeutics.

Application

• Liposomal Drug Delivery: A key component in the formulation of stable, targeted liposomes for encapsulating and delivering hydrophobic or hydrophilic active pharmaceutical ingredients (APIs).
• Biomimetic Membrane Research: Used to construct synthetic cell membranes and vesicles for studying membrane fluidity, permeability, and protein-lipid interactions.
• Nanoparticle Stabilization: Acts as a functional surfactant or co-lipid to enhance the colloidal stability and surface properties of lipid nanoparticles (LNPs) and other nanocarriers.
• Diagnostic Agent Formulation: Employed in the development of contrast agents and diagnostic probes for medical imaging techniques.
• Gene Therapy Vectors: Investigated as a component in non-viral vectors for the efficient and safe delivery of nucleic acids (DNA, RNA).
• Cosmetic Actives Carrier: Utilized in high-end cosmetic formulations to improve the skin penetration and stability of sensitive active ingredients.

Basic Information

Product Name	2-Acetyl-S-Octadecyl-1-Thioglycero-3-Phosphocholine
CAS No.	89314-81-8
Molecular Formula	C28H58NO6PS
Molecular Weight	567.79 g/mol
Synonyms	1-O-Octadecyl-2-acetyl-sn-glycero-3-phosphocholine; S-Octadecyl-2-acetylthio-1-ethylphosphorylcholine; Acetylated Lyso-PAF C-18 Thioether; 1-S-Octadecyl-2-acetyl-sn-glycero-3-phosphocholine; 2-Acetyl-1-S-octadecylglycero-3-phosphocholine; Thioether PAF Analog C18; Phospholipid Thioether Derivative
EINECS	Contact for details

Quality Control

Every batch of 2-Acetyl-S-Octadecyl-1-Thioglycero-3-Phosphocholine is manufactured and analyzed under strict quality management protocols. We ensure compliance with relevant industry standards for research-grade and pharmaceutical intermediate materials. Comprehensive analytical testing, including HPLC, NMR, and MS, is performed to verify identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature and tendency to be easily oxidized, long-term storage is recommended under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C). For optimal stability, store in a cool, dry, and well-ventilated area separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.