Description

S-(1,2,3,4,4-Pentachloro-1,3-Butadienyl)Glutathione is a specialized biochemical conjugate formed between glutathione and a reactive pentachlorobutadiene moiety. This compound is of significant interest in toxicology and metabolic research, serving as a critical marker for studying the metabolic pathways and detoxification mechanisms of chlorinated organic compounds. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and chemical safety testing facilities investigating bioactivation, covalent binding, and glutathione-dependent metabolism.

Application

• Biochemical Research: Used as a reference standard or intermediate in studies of glutathione S-transferase (GST) mediated metabolism and detoxification pathways.
• Toxicology Studies: Serves as a model compound for investigating the formation and role of reactive metabolites and glutathione conjugates in the toxicity of polyhalogenated hydrocarbons.
• Metabolite Identification: Employed in analytical method development (e.g., LC-MS/MS) for the identification and quantification of specific glutathione adducts in biological samples.
• Mechanistic Toxicology: Aids in understanding the bioactivation mechanisms of industrial solvents and environmental contaminants like hexachlorobutadiene.
• Reference Material: Acts as a high-purity analytical standard for calibration and validation in environmental and biological monitoring.

Basic Information

Item	Details
Product Name	S-(1,2,3,4,4-Pentachloro-1,3-Butadienyl)Glutathione
CAS No.	89021-88-5
Molecular Formula	C14H17Cl5N3O6S
Molecular Weight	548.58 g/mol
Synonyms	1,2,3,4,4-Pentachloro-1,3-butadienyl Glutathione; S-(Pentachlorobutadienyl)glutathione; Glutathione S-(pentachlorobutadiene) conjugate; PCBD-GSH; GSH conjugate of hexachlorobutadiene metabolite; N-(N-L-γ-Glutamyl-3-sulfanyl-L-alanyl)glycine 1-(1,2,3,4,4-pentachloro-1,3-butadienyl) ester
EINECS	Contact for details

Quality Control

Our S-(1,2,3,4,4-Pentachloro-1,3-Butadienyl)Glutathione is produced under controlled conditions to ensure high purity and batch-to-batch consistency suitable for research applications. Quality is verified through a suite of analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the product label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed tightly after each use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.