Description

Naloxone Fluorescein CAS NO 88641-41-2 is a specialized fluorescent-labeled derivative of the opioid antagonist naloxone. This compound is a critical research tool for visualizing and studying opioid receptor binding, distribution, and dynamics in biological systems. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic developers in the fields of neuroscience, pharmacology, and molecular imaging.

Application

• Opioid Receptor Research: Fluorescent probe for in vitro and ex vivo visualization of opioid receptor sites via fluorescence microscopy.
• Competitive Binding Assays: Used in high-throughput screening (HTS) to identify and characterize new opioid receptor ligands and antagonists.
• Cellular Imaging: Tracing receptor internalization, trafficking, and localization in live or fixed cell cultures.
• Tissue Staining: Histological staining of brain and neural tissue sections to map receptor density and distribution.
• Flow Cytometry: Labeling cells expressing opioid receptors for analysis and sorting.
• Diagnostic Probe Development: Serving as a precursor or model compound for developing diagnostic imaging agents.
• Mechanistic Studies: Investigating the pharmacokinetics and binding kinetics of naloxone and related compounds.

Basic Information

Product Name	Naloxone Fluorescein
CAS No.	88641-41-2
Molecular Formula	C34H32N2O8
Molecular Weight	596.63 g/mol
Synonyms	Naloxone Fluorescein Isothiocyanate; Naloxone-FITC; Fluorescein Isothiocyanate Naloxone; FITC-Naloxone; 17-Allyl-4,5α-epoxy-3,14-dihydroxymorphinan-6-one fluorescein conjugate; Naloxone FITC Conjugate; Opioid Receptor Fluorescent Tracer; Naloxone derivative labeled with FITC
EINECS	Contact for details

Quality Control

Our Naloxone Fluorescein is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, fluorescence properties, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be kept under desiccant in its original packaging. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Orange to red solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Fluorescence Properties	Ex/Em ~494/518 nm
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.