Description

n-Succinimidyl 11-(Maleimido)Undecanoate is a heterobifunctional crosslinking reagent featuring an amine-reactive NHS ester and a thiol-reactive maleimide group, separated by an extended 11-carbon spacer. This molecular architecture is critical for creating stable amide bonds with primary amines while enabling subsequent, site-specific conjugation to sulfhydryl groups, minimizing unwanted self-polymerization. It is an essential tool for researchers and manufacturers in bioconjugation, antibody-drug conjugate (ADC) development, and protein labeling, where controlled linkage and preserved biological activity are paramount.

Application

• Antibody-Drug Conjugate (ADC) Linker: Facilitates the stable conjugation of cytotoxic payloads to monoclonal antibodies via lysine and cysteine residues.
• Protein-Protein/Peptide Conjugation: Enables the crosslinking of different biomolecules for creating bispecific constructs or protein complexes.
• Enzyme and Protein Immobilization: Used to covalently attach proteins to solid supports (e.g., beads, sensors, chips) for assays and diagnostics.
• Fluorescent & Biotin Labeling of Biomolecules: Conjugates dyes, probes, or biotin to antibodies, peptides, or other proteins for detection and imaging applications.
• Polymer Functionalization: Introduces reactive maleimide groups onto amine-containing polymers for further bioconjugation in drug delivery systems.
• Surface Modification: Creates maleimide-activated surfaces on plates or nanoparticles for specific capture of thiol-containing ligands.

Basic Information

Product Name	n-Succinimidyl 11-(Maleimido)Undecanoate
CAS No.	87981-04-2
Molecular Formula	C19H28N2O6
Molecular Weight	380.44 g/mol
Synonyms	11-Maleimidoundecanoic Acid N-Hydroxysuccinimide Ester; SM(PEG)11; NHS-PEG11-Maleimide; Maleimidoundecanoic Acid N-Succinimidyl Ester; N-(11-Maleimidoundecanoyloxy)succinimide; KMUS; Heterobifunctional Crosslinker (NHS-PEGn-Maleimide); N-Succinimidyl 11-Maleimidoundecanoate
EINECS	Contact for details

Quality Control

Our n-Succinimidyl 11-(Maleimido)Undecanoate is manufactured under strict quality systems to ensure batch-to-batch consistency and high performance in sensitive bioconjugation applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR). Certificates of Analysis (COA) with detailed specifications are provided to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.