Description

S-(2-(N(7)-Guanyl)Ethyl)Glutathione is a specialized glutathione adduct, a key biochemical tool for studying DNA alkylation damage and repair mechanisms. This compound matters for its role in elucidating cellular detoxification pathways and the formation of specific DNA-protein crosslinks. It is primarily needed by research institutions and pharmaceutical companies engaged in molecular toxicology, cancer research, and the development of chemoprotective agents.

Application

• Biochemical Research: As a critical reference standard and substrate in studies of DNA adduct formation and repair.
• Toxicology Studies: For investigating the metabolic pathways and detoxification of alkylating agents and carcinogens.
• Cancer Research: Used to model and understand the mechanisms of action of certain chemotherapeutic drugs and cellular resistance.
• Analytical Standard: Serves as a high-purity standard for HPLC, LC-MS, and other analytical methods in bioanalytical laboratories.
• Enzyme Activity Assays: Employed in assays for glutathione S-transferase (GST) and other related enzyme activities.

Basic Information

Product Name	S-(2-(N(7)-Guanyl)Ethyl)Glutathione
CAS No.	87367-17-7
Molecular Formula	C17H27N7O7S
Molecular Weight	473.51 g/mol
Synonyms	S-[2-(7-Guaninyl)ethyl]glutathione; N7-(2-Glutathionyl)ethylguanine; Guanine-7-ethylglutathione; GSH-N7-EtG; Glutathione-N7-ethylguanine adduct; S-(2-(7-Guaninyl)ethyl)-L-glutathione; DNA-Glutathione Crosslink Model Compound
EINECS	Contact for details

Quality Control

Our S-(2-(N(7)-Guanyl)Ethyl)Glutathione is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is hygroscopic (moisture-sensitive) and easily oxidized. For short-term use, store desiccated at 2-8°C. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, DMSO; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.